Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fhl1tm1Chen mutation
(0 available);
any
Fhl1 mutation
(8 available)
Tg(Myh6-Gnaq)25Gwd mutation
(0 available)
|
|
|
cardiovascular system
 N |
• cardiomyopathy induced by the expression of the transgene is rescued
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-Gnaq)25Gwd mutation
(0 available)
Tg(Myh6-Gnaq)40Gwd mutation
(1 available)
|
|
|
mortality/aging
cardiovascular system
|
|
• massive enlargement and dilation of all four cardiac chambers
|
|
|
• ventricles show mild to moderate cellular edema with little or no myocyte loss
|
|
|
• spontaneous cardiac decompensation is seen in 3 of 6 double mutants
|
respiratory system
|
|
• lung/body weight ratio averages 40% more than in controls
|
|
|
• large bilateral pleural effusions
|
|
|
• 3 of 6 double mutants become tachypneic between 11 and 14 weeks of age
|
|
|
• 3 of 6 double mutants develop severe respiratory distress between 11 and 14 weeks of age
|
muscle
homeostasis/metabolism
growth/size/body
|
|
• massive enlargement and dilation of all four cardiac chambers
|
|
|
• lung/body weight ratio averages 40% more than in controls
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
|
|
|
cardiovascular system
|
|
• mice exhibit an increased interventricular septal thickness compared to in wild-type mice
|
|
|
• heart weight is 25% greater than in controls and cardiomyocyte dimensions are larger
|
|
|
• mice exhibit an increase in left ventricle posterior wall thickness compared to in wild-type mice
|
|
|
• fractional shortening is depressed
(J:41949)
• the normal beta-adrenergic (via dobutamine) augmentation of cardiac contractility and relaxation is absent in mutants
(J:41949)
|
|
|
• reduction in contractility of left ventricle
|
|
|
• heart rate is slower during conscious blood pressure measurements and anesthetized echocardiographic studies
|
muscle
|
|
• fractional shortening is depressed
(J:41949)
• the normal beta-adrenergic (via dobutamine) augmentation of cardiac contractility and relaxation is absent in mutants
(J:41949)
|
|
|
• reduction in contractility of left ventricle
|
growth/size/body
|
|
• heart weight is 25% greater than in controls and cardiomyocyte dimensions are larger
|
Analysis Tools
