Phenotypes associated with this allele

• Allele Symbol: Klf9^tm1Yfk
• Allele Name: targeted mutation 1, Yoshiaki Fujii-Kuriyama
• Allele ID: MGI:2654224
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Klf9^tm1Yfk/Klf9^tm1Yfk	B6.129P2-Klf9^tm1Yfk/J	MGI:6272001
hm2	Klf9^tm1Yfk/Klf9^tm1Yfk	involves: 129P2/OlaHsd * C57BL/6J	MGI:2654225

Genotype
MGI:6272001

hm1

• Allelic Composition: Klf9^tm1Yfk/Klf9^tm1Yfk
• Genetic Background: B6.129P2-Klf9^tm1Yfk/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:200159 )

♀N • females in which endometriosis is surgically induced show minimal endometriotic implant-associated growth and fibrosis similar to that seen in controls

Genotype
MGI:2654225

hm2

• Allelic Composition: Klf9^tm1Yfk/Klf9^tm1Yfk
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

behavior/neurological

behavior/neurological phenotype ( J:82509 )

N • homozygotes exhibit only slight (insignificant) differences in locomotor activities, rearing behavior, and speed of movement or no differences in the rod-walking test, light-dark choice test, horizontal wire-hanging test, or gait measurements relative to wild-type littermates

impaired contextual conditioning behavior ( J:82509 )

• homozygotes exhibit a significant deficit in contextual freezing response, both immediately (immediate after shock freezing) and 1 day (delayed freezing) after the shock is presented

• however, homozygotes display normal jumping and vocalization reactions in response to increasing electrical foot shocks, indicating that pain sensitivity and physical response to pain are not significantly altered

impaired coordination ( J:82509 )

• homozygotes display a performance deficit on the rotating rod test, failing to improve performance after daily training