Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddit3tm1Dron mutation
(1 available);
any
Ddit3 mutation
(20 available)
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immune system
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• under cholesterol loading conditions, macrophages treated exhibit less apoptosis compared with similarly treated wild-type macrophages
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• macrophages treated with excess lipoprotein-cholesterol or tunicamycin fail to exhibit an increase in IP3-induced calcium release unlike similarly wild-type
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cellular
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• under cholesterol loading conditions, macrophages treated exhibit less apoptosis compared with similarly treated wild-type macrophages
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hematopoietic system
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• under cholesterol loading conditions, macrophages treated exhibit less apoptosis compared with similarly treated wild-type macrophages
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• macrophages treated with excess lipoprotein-cholesterol or tunicamycin fail to exhibit an increase in IP3-induced calcium release unlike similarly wild-type
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Allelic
Composition |
Ddit3tm1Dron/Ddit3tm1Dron
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Genetic
Background |
either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1) |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddit3tm1Dron mutation
(1 available);
any
Ddit3 mutation
(20 available)
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cellular
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• homozygotes treated with tunicamycin to induce ER stress and renal insufficiency exhibit decreased programmed cell death in the renal proximal tubular epithelium
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• MEFs prepared from E13.5 embryos exhibit less programmed cell death when challenged with agents that perturb ER function
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddit3tm1Dron mutation
(1 available);
any
Ddit3 mutation
(20 available)
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endocrine/exocrine glands
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N |
• homozygotes have a normal pancreas
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddit3tm1Dron mutation
(1 available);
any
Ddit3 mutation
(20 available)
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immune system
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• homozygotes infected with a neurovirulent virus, Moloney MLV-ts1, exhibit a small, but significant, delay of about 4.5 days in the incubation period of the disease that correlates with a decrease in early virus replication
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddit3tm1Dron mutation
(1 available);
any
Ddit3 mutation
(20 available)
Mpztm3.1Wra mutation
(0 available);
any
Mpz mutation
(28 available)
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behavior/neurological
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• mice show no improvement in rotarod function, with nice unable to retain balance on the rotarod
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nervous system
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• mice show no morphological changes in myelin, showing very thin, if any, myelin in sciatic nerves
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• mice show no improvement in myelination
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• mice show no changes in nerve conduction velocities, showing severely slowed nerve conduction velocities at 6-8 weeks of age
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddit3tm1Dron mutation
(1 available);
any
Ddit3 mutation
(20 available)
Tg(Col2a1-rtTA,tetO-COMP*)2Jath mutation
(0 available)
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immune system
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• doxycycline treated mice show decreased levels of inflammatory markers in the growth plate compared to Tg(Col2a1-rtTA,tetO-COMP*)2Jath/0 mice
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Analysis Tools