Phenotypes associated with this allele

• Allele Symbol: Tg(SV40-Ahr)1Poe
• Allele Name: transgene insertion 1, Lorenz Poellinger
• Allele ID: MGI:2654022
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(SV40-Ahr)1Poe/0	involves: C57BL/6 * CBA	MGI:2654028

Genotype
MGI:2654028

tg1

• Allelic Composition: Tg(SV40-Ahr)1Poe/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:77977 )

• death by 12 months of age, beginning at 6 months of age

• males die earlier than females

neoplasm

increased stomach tumor incidence ( J:77977 )

• develop severe tumors that invade all stomach layers and adhere to surrounding organs

• severity of gastric tumors increases with age and males are more affected than females

digestive/alimentary system

abnormal cecum morphology ( J:77977 )

• focally located squamous cysts are seen in the cecum after 6 months of age

abnormal ileum morphology ( J:77977 )

• focally located squamous cysts are seen occasionally in the ileum at after 6 months of age

abnormal stomach wall morphology ( J:77977 )

• thick stomach wall throughout the cardia and corpus regions of the glandular stomach

abnormal stomach glandular epithelium morphology ( J:77977 )

• the proliferative zone of the glandular gastric mucosa is expanded basally to include the parietal and chief cell region

gastric metaplasia ( J:77977 )

• intestinal metaplasia in the stomach

increased stomach tumor incidence ( J:77977 )

• develop severe tumors that invade all stomach layers and adhere to surrounding organs

• severity of gastric tumors increases with age and males are more affected than females

hematopoietic system

decreased thymus weight ( J:77977 )

• gradual decrease in thymus weight up to 6 months of age

increased pro-B cell number ( J:82428 )

• slight increase of pro-B cells

decreased B-1 B cell number ( J:82428 )

• reduction of B1 cells in the peritoneal cavity

absent B-1a cells ( J:82428 )

increased mature B cell number ( J:82428 )

• increase in the mature B cell population in the bone marrow

• increase in the mature B cell population in the spleen at 5 weeks of age, although numbers are normal at 3-9 months

increased B-2 B cell number ( J:82428 )

• increase in the mature B cell populations in the bone marrow and spleen

increased pre-B cell number ( J:82428 )

• population of pre-B cells and virgin B cells (B220+CD43-IgM-) is mildly increased

immune system

decreased thymus weight ( J:77977 )

• gradual decrease in thymus weight up to 6 months of age

increased pro-B cell number ( J:82428 )

• slight increase of pro-B cells

decreased B-1 B cell number ( J:82428 )

• reduction of B1 cells in the peritoneal cavity

absent B-1a cells ( J:82428 )

increased mature B cell number ( J:82428 )

• increase in the mature B cell population in the bone marrow

• increase in the mature B cell population in the spleen at 5 weeks of age, although numbers are normal at 3-9 months

increased B-2 B cell number ( J:82428 )

• increase in the mature B cell populations in the bone marrow and spleen

increased pre-B cell number ( J:82428 )

• population of pre-B cells and virgin B cells (B220+CD43-IgM-) is mildly increased

liver/biliary system

increased liver weight ( J:77977 )

• gradual increase in liver weight

endocrine/exocrine glands

decreased thymus weight ( J:77977 )

• gradual decrease in thymus weight up to 6 months of age

growth/size/body

increased liver weight ( J:77977 )

• gradual increase in liver weight