Phenotypes associated with this allele

• Allele Symbol: Il13ra2^tm1Gru
• Allele Name: targeted mutation 1, Michael Grusby
• Allele ID: MGI:2653910
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il13ra2^tm1Gru/Il13ra2^tm1Gru	B6.Cg-Il13ra2^tm1Gru	MGI:5903463
hm2	Il13ra2^tm1Gru/Il13ra2^tm1Gru	C.Cg-Il13ra2^tm1Gru	MGI:2653911

Genotype
MGI:5903463

hm1

• Allelic Composition: Il13ra2^tm1Gru/Il13ra2^tm1Gru
• Genetic Background: B6.Cg-Il13ra2^tm1Gru

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

abnormal susceptibility to injury induced morbidity/mortality ( J:236976 )

• increased following exposure to 100% oxygen

respiratory system

increased lung apoptosis ( J:236976 )

• mice exposed to 100% oxygen exhibit exaggerated lung apoptosis in airway and alveolar epithelial cells compared with wild-type mice

homeostasis/metabolism

abnormal susceptibility to injury induced morbidity/mortality ( J:236976 )

• increased following exposure to 100% oxygen

increased susceptibility to injury ( J:236976 )

• mice exposed to 100% oxygen exhibit exaggerated lung apoptosis in airway and alveolar epithelial cells with increased bronchoalveolar total protein and decreased survival compared with wild-type mice

cellular

increased lung apoptosis ( J:236976 )

• mice exposed to 100% oxygen exhibit exaggerated lung apoptosis in airway and alveolar epithelial cells compared with wild-type mice

Genotype
MGI:2653911

hm2

• Allelic Composition: Il13ra2^tm1Gru/Il13ra2^tm1Gru
• Genetic Background: C.Cg-Il13ra2^tm1Gru

hematopoietic system

abnormal bone marrow cell morphology/development ( J:82376 )

♀ • significantly higher frequencies of bone marrow macrophage progenitors per femur as shown by increased macrophage colony formation

♀ • however, frequency of immature bone marrow erythroid precursors (TER-119), splenic colony formation, and peripheral blood lymphocyte populations are normal

decreased erythroid progenitor cell number ( J:82376 )

♀ • frequencies of immature erythroid (BFU-E) progenitors per femur are significantly reduced

increased IgA level ( J:82376 )

♀ • significantly increased serum IgA levels

increased IgE level ( J:82376 )

♀ • significantly increased serum IgE levels

increased IgG2a level ( J:82376 )

♀ • significantly increased serum IgG2a levels

increased IgG2b level ( J:82376 )

♀ • significantly increased serum IgG2b levels

abnormal macrophage physiology ( J:82376 )

♀

immune system

increased IgA level ( J:82376 )

♀ • significantly increased serum IgA levels

increased IgE level ( J:82376 )

♀ • significantly increased serum IgE levels

increased IgG2a level ( J:82376 )

♀ • significantly increased serum IgG2a levels

increased IgG2b level ( J:82376 )

♀ • significantly increased serum IgG2b levels

abnormal macrophage physiology ( J:82376 )

♀

decreased circulating interleukin-13 level ( J:82376 )

♀ • serum interleukin-13 levels are significantly reduced or absent

♀ • in contrast, lung and liver interleukin-13 levels are increased

increased interferon-gamma secretion ( J:82376 )

♀ • ~2-fold increase in interferon gamma production from mutant spleen cells in response to activation with anti-CD3

increased interleukin-10 secretion ( J:82376 )

♀ • significantly increased IL-10 production from mutant spleen cells in response to activation with anti-CD3

decreased interleukin-4 secretion ( J:82376 )

♀ • significantly reduced IL-4 production from mutant spleen cells in response to activation with anti-CD3

decreased susceptibility to endotoxin shock ( J:82376 )

♀ • decreased in vitro sensitivity of resident peritoneal macrophages to LPS, as determined by NO production

homeostasis/metabolism

decreased circulating interleukin-13 level ( J:82376 )

♀ • serum interleukin-13 levels are significantly reduced or absent

♀ • in contrast, lung and liver interleukin-13 levels are increased