All Phenotypes Ntf3<tm1Esm> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ntf3^tm1Esm
targeted mutation 1, Erin M Schuman
MGI:2653300

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ntf3^tm1Esm/Ntf3^tm1Esm	involves: 129S1/Sv	MGI:2653301
cn2	Ntf3^tm1Esm/Ntf3^tm1Esm Foxg1^tm1(cre)Skm/Foxg1⁺	involves: 129P2/OlaHsd * 129S1/Sv	MGI:2653845
cn3	Ntf3^tm1Esm/Ntf3^tm1Esm Tg(Syn1-cre)671Jxm/0	involves: 129S1/Sv * C57BL/6 * CBA	MGI:2653303
cn4	Ntf3^tm1Esm/Ntf3^tm1Esm Tg(GFAP-cre)25Mes/0	involves: 129S1/Sv * FVB/N	MGI:4436771

Allelic Composition	Ntf3^tm1Esm/Ntf3^tm1Esm
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntf3^tm1Esm mutation (0 available); any Ntf3 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:82354 )

Allelic Composition	Ntf3^tm1Esm/Ntf3^tm1Esm Foxg1^tm1(cre)Skm/Foxg1⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1^tm1(cre)Skm mutation (2 available); any Foxg1 mutation (28 available)
Ntf3^tm1Esm mutation (0 available); any Ntf3 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal vision ( J:81563 )

• impaired visual function indicated by the visual cliff avoidance test: mutants often cross the cliff edge without hesitation and show no preference for either side of the box

nervous system

decreased CNS synapse formation ( J:81563 )

• reduced thalamocortical synaptic interactions

abnormal nervous system tract morphology ( J:81563 )

• thalamthalamocortical projections are similar to controls at P0, but by P3, axonal bundles projecting from the thalamus through the cortical white matter are reducedcortical projections are similar to controls at P0, but by P3, thalamocortical projection is reduced

• reduction in the number of lateral geniculate nucleus projections to the visual cortex and anteroventral and laterodorsal nuclei projections to retrosplenial cortex

Allelic Composition	Ntf3^tm1Esm/Ntf3^tm1Esm Tg(Syn1-cre)671Jxm/0
Genetic Background	involves: 129S1/Sv * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntf3^tm1Esm mutation (0 available); any Ntf3 mutation (24 available)
Tg(Syn1-cre)671Jxm mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:82354 )

N	• mutants exhibit normal synaptic transmission, with no differences in paired-pulse facilitation, post-tetanic potentiation, or long-term potentiation

Allelic Composition	Ntf3^tm1Esm/Ntf3^tm1Esm Tg(GFAP-cre)25Mes/0
Genetic Background	involves: 129S1/Sv * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntf3^tm1Esm mutation (0 available); any Ntf3 mutation (24 available)
Tg(GFAP-cre)25Mes mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal nervous system tract morphology ( J:81563 )

• loss of subcortical tract results in a reduction in axonal bundles in subcortical white matter

vision/eye

abnormal vision ( J:81563 )

• impaired visual function indicated by the visual cliff avoidance test: mutants often cross the cliff edge without hesitation and show no preference for either side of the box

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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