Phenotypes associated with this allele

• Allele Symbol: Scd1^ab-Xyk
• Allele Name: kunming
• Allele ID: MGI:2653202
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Scd1^ab-Xyk/Scd1^ab-Xyk	Kunming-Scd1^ab-Xyk	MGI:3656047

Genotype
MGI:3656047

hm1

• Allelic Composition: Scd1^ab-Xyk/Scd1^ab-Xyk
• Genetic Background: Kunming-Scd1^ab-Xyk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal sebocyte morphology ( J:93033 )

• some normal sebocytes but most small eosinophilic with vacuolated cytoplasm

abnormal skin sebaceous gland morphology ( J:93033 )

sebaceous gland hypoplasia ( J:93033 )

• hypoplasia of skin sebaceous glands

vision/eye

eyelids fail to open ( J:93033 )

• eyelids do not open normally

integument

abnormal sebocyte morphology ( J:93033 )

• some normal sebocytes but most small eosinophilic with vacuolated cytoplasm

sebaceous gland hypoplasia ( J:93033 )

• hypoplasia of skin sebaceous glands

abnormal hair growth ( J:93033 )

alopecia ( J:93033 )

• progressive alopecia develops with age

short hair ( J:93033 )

• at 7 days

sparse hair ( J:93033 )

• at 7 days

abnormal hair follicle morphology ( J:93033 )

• foreign body granulomas leading to microulcers develop around hair fibers

• older mice with occasional dilated follicles filled with laminated cornified material

abnormal hair follicle inner root sheath morphology ( J:93033 )

• inner root sheath fails to degrade normally resulting in rupture of hair follicles within the hypodermal fat layer as they entered catagen

abnormal hair follicle outer root sheath morphology ( J:93033 )

• elongated nuclei in cells of outer root sheath

distorted hair follicle pattern ( J:93033 )

• parallel arrangement of hair follicles lost

abnormal skin morphology ( J:93033 )

abnormal skin sebaceous gland morphology ( J:93033 )

thick epidermis ( J:93033 )

• mild to moderately thickened epidermis

dry skin ( J:93033 )

• dry skin with white flaking

flaky skin ( J:93033 )

• dry skin with white flaking

wrinkled skin ( J:93033 )

• rugate skin

abnormal skin condition ( J:93033 )

decreased skin tensile strength ( J:93033 )

• skin is easily lacerated