Phenotypes associated with this allele

• Allele Symbol: Hcar2^tm1Soff
• Allele Name: targeted mutation 1, Stefan Offermanns
• Allele ID: MGI:2653103
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hcar2^tm1Soff/Hcar2^tm1Soff	involves: 129P2/OlaHsd * C57BL/6	MGI:2653109

Genotype
MGI:2653109

hm1

• Allelic Composition: Hcar2^tm1Soff/Hcar2^tm1Soff
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal lipid homeostasis ( J:82225 )

• the high-affinity binding capacity for nicotinic acid was reduced by >75% in mutant adipocyte plasma membranes relative to wild-type membranes

• in vitro, the nicotinic acid-induced inhibition of free fatty acid (FFA) release from isolated adipocytes was absent from homozygous mutant fat cells

• following 24 hours of starvation, wild-type mice exhibited higher basal levels of FFAs than homozygous mutant mice

• within 15 min, i.p. injection of nicotinic acid resulted in a marked reduction in plasma levels of FFAs in wild-type and heterozygous mutant mice which lasted >1 hour; instead, homozygous mutant mice displayed a small increase in FFAs after 15 min, which was also observed in control mice that received only the carrier solution

• following a 2-week period on a high-fat diet, nicotinic acid administration resulted in a ~30% reduction of triglycerides in wild-type mice, but had no effect on triglyceride levels in mutant mice