All Phenotypes Ogg1<tm1Yun> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ogg1^tm1Yun/Ogg1^tm1Yun	involves: 129S/SvEv * C57BL/6J	MGI:2653016
hm2	Ogg1^tm1Yun/Ogg1^tm1Yun	involves: 129S/SvEv * C57BL/6JJcl	MGI:5476991
cx3	Mutyh^tm1Yun/Mutyh^tm1Yun Nudt1^tm1Tts/Nudt1^tm1Tts Ogg1^tm1Yun/Ogg1^tm1Yun	B6JJcl.129-Mutyh^tm1Yun Nudt1^tm1Tts Ogg1^tm1Yun	MGI:5476986
cx4	Nudt1^tm1Tts/Nudt1^tm1Tts Ogg1^tm1Yun/Ogg1^tm1Yun	involves: 129S/SvEv * C57BL/6J	MGI:2653017
cx5	Mutyh^tm1Yun/Mutyh^tm1Yun Ogg1^tm1Yun/Ogg1^tm1Yun	involves: 129S/SvEv * C57BL/6JJcl	MGI:5476987
cx6	Nudt1^tm1Tts/Nudt1^tm1Tts Ogg1^tm1Yun/Ogg1^tm1Yun	involves: 129S/SvEv * C57BL/6JJcl	MGI:5476988

Allelic Composition	Ogg1^tm1Yun/Ogg1^tm1Yun
Genetic Background	involves: 129S/SvEv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ogg1^tm1Yun mutation (1 available); any Ogg1 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased lung adenoma incidence ( J:82287 )

• spontaneously developed in Ogg1 knockout mice approximately 1.5 years after birth

increased lung carcinoma incidence ( J:82287 )

• spontaneously developed in Ogg1 knockout mice approximately 1.5 years after birth

respiratory system

increased lung adenoma incidence ( J:82287 )

• spontaneously developed in Ogg1 knockout mice approximately 1.5 years after birth

increased lung carcinoma incidence ( J:82287 )

• spontaneously developed in Ogg1 knockout mice approximately 1.5 years after birth

Allelic Composition	Ogg1^tm1Yun/Ogg1^tm1Yun
Genetic Background	involves: 129S/SvEv * C57BL/6JJcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ogg1^tm1Yun mutation (1 available); any Ogg1 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

microgliosis ( J:193978 )

increased susceptibility to neuronal excitotoxicity ( J:193978 )

neurodegeneration ( J:193978 )

behavior/neurological

decreased vertical activity ( J:193978 )

decreased locomotor activity ( J:193978 )

cellular

microgliosis ( J:193978 )

increased susceptibility to neuronal excitotoxicity ( J:193978 )

homeostasis/metabolism

increased susceptibility to neuronal excitotoxicity ( J:193978 )

immune system

microgliosis ( J:193978 )

hematopoietic system

microgliosis ( J:193978 )

Allelic Composition	Mutyh^tm1Yun/Mutyh^tm1Yun Nudt1^tm1Tts/Nudt1^tm1Tts Ogg1^tm1Yun/Ogg1^tm1Yun
Genetic Background	B6JJcl.129-Mutyh^tm1Yun Nudt1^tm1Tts Ogg1^tm1Yun

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mutyh^tm1Yun mutation (2 available); any Mutyh mutation (34 available)
Nudt1^tm1Tts mutation (0 available); any Nudt1 mutation (27 available)
Ogg1^tm1Yun mutation (1 available); any Ogg1 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor incidence ( J:193978 )

• mice are highly susceptible to spontaneous tumorigenesis within 100 days of birth

Allelic Composition	Nudt1^tm1Tts/Nudt1^tm1Tts Ogg1^tm1Yun/Ogg1^tm1Yun
Genetic Background	involves: 129S/SvEv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nudt1^tm1Tts mutation (0 available); any Nudt1 mutation (27 available)
Ogg1^tm1Yun mutation (1 available); any Ogg1 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:82287 )

N	• no tumors in the lungs of double knockout mice, unlike Ogg^tm1Skmi single knockout mice

Allelic Composition	Mutyh^tm1Yun/Mutyh^tm1Yun Ogg1^tm1Yun/Ogg1^tm1Yun
Genetic Background	involves: 129S/SvEv * C57BL/6JJcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mutyh^tm1Yun mutation (2 available); any Mutyh mutation (34 available)
Ogg1^tm1Yun mutation (1 available); any Ogg1 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased susceptibility to neuronal excitotoxicity ( J:193978 )

• 3-NP-treated mice exhibit better motor performance with neither medium spiny neuron loss, microgliosis nor single strand break accumulation compared with Ogg1^tm1Skmi homozygotes

cellular

decreased susceptibility to neuronal excitotoxicity ( J:193978 )

• 3-NP-treated mice exhibit better motor performance with neither medium spiny neuron loss, microgliosis nor single strand break accumulation compared with Ogg1^tm1Skmi homozygotes

homeostasis/metabolism

decreased susceptibility to neuronal excitotoxicity ( J:193978 )

• 3-NP-treated mice exhibit better motor performance with neither medium spiny neuron loss, microgliosis nor single strand break accumulation compared with Ogg1^tm1Skmi homozygotes

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

microgliosis ( J:193978 )

• in 3-NP-treated mice, especially in the dorsal striatum

increased susceptibility to neuronal excitotoxicity ( J:193978 )

• striatal degeneration in 3-NP-treated mice

• however, calpain and PARP inhibitors suppress striatal neurodegeneration and behavioral impairments

neurodegeneration ( J:193978 )

• striatal degeneration in 3-NP-treated mice

• however, calpain and PARP inhibitors suppress striatal neurodegeneration and behavioral impairments

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:193978 )

• 3-NP treated mice exhibit increased motor impairment (neurological score based on: general slowness of displacement resulting from mild hindlimb impairment;, incoordination and marked gait abnormality; hindlimb paralysis; incapacity to move resulting from forelimb and hindlimb impairment) compared with wild-type mice

decreased vertical activity ( J:193978 )

• in 3-NP-treated mice

decreased locomotor activity ( J:193978 )

• 3-NP-treated mice travel less distance in an open-field test compared with wild-type mice that is more severe than in Ogg1^tm1Skmi homozygotes

• 3-NP-treated mice are hypoactive in home cages compared with wild-type mice

• however, calpain and PARP inhibitors suppress striatal neurodegeneration and behavioral impairments

cellular

microgliosis ( J:193978 )

• in 3-NP-treated mice, especially in the dorsal striatum

increased susceptibility to neuronal excitotoxicity ( J:193978 )

• striatal degeneration in 3-NP-treated mice

• however, calpain and PARP inhibitors suppress striatal neurodegeneration and behavioral impairments

abnormal single-strand DNA break repair ( J:193978 )

• 3-NP treated mice exhibit an accumulation of 8-oxoG that results in the accumulation of single strand breaks in mitochondrial DNA of striatal medium spiny neurons and nuclear DNA of striatal microglia compared with wild-type mice

homeostasis/metabolism

increased susceptibility to neuronal excitotoxicity ( J:193978 )

• striatal degeneration in 3-NP-treated mice

• however, calpain and PARP inhibitors suppress striatal neurodegeneration and behavioral impairments

abnormal single-strand DNA break repair ( J:193978 )

immune system

microgliosis ( J:193978 )

• in 3-NP-treated mice, especially in the dorsal striatum

hematopoietic system

microgliosis ( J:193978 )

• in 3-NP-treated mice, especially in the dorsal striatum

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/30/2025 MGI 6.24