Phenotypes associated with this allele

• Allele Symbol: Kitl^Sl-18R
• Allele Name: steel 18 Oak Ridge
• Allele ID: MGI:2652945
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kitl^Sl-18R/Kitl^Sl-18R	C3.Cg-Kitl^Sl-18R	MGI:2652986
ht2	Kitl^Sl-18R/Kitl^+	C3.Cg-Kitl^Sl-18R	MGI:2652992

Genotype
MGI:2652986

hm1

• Allelic Composition: Kitl^Sl-18R/Kitl^Sl-18R
• Genetic Background: C3.Cg-Kitl^Sl-18R

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:82263 )

• only 53% of the expected numbers of homozygotes are observed at P1, similar to the percentage seen in Kitl^Sl-gb homozygotes (46%)

postnatal lethality, complete penetrance ( J:82263 )

• almost 25% of homozygotes live past P2, unlike age-matched Kitl^Sl-gb homozygotes

• however, no homozygotes survive beyond P7

hematopoietic system

low mean erythrocyte cell number ( J:82263 )

• at P1, mean peripheral RBC counts are reduced to only 18% of wild-type controls, similar to mean RBC counts seen in age-matched Kitl^Sl-gb homozygotes

Genotype
MGI:2652992

ht2

• Allelic Composition: Kitl^Sl-18R/Kitl⁺
• Genetic Background: C3.Cg-Kitl^Sl-18R

hematopoietic system

decreased erythrocyte cell number ( J:82263 )

• at P1, mean peripheral RBC counts are 80% of wild-type values, suggesting a slightly milder anemia than that seen in age-matched Kitl^Sl-gb heterozygotes (71% of wild-type values)