Phenotypes associated with this allele

• Allele Symbol: Krt10^tm1Der
• Allele Name: targeted mutation 1, Dennis R Roop
• Allele ID: MGI:2652788
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Krt10^tm1Der/Krt10^tm1Der Tg(KRT14-cre/PGR)1Der/0	involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR	MGI:2652793
cn2	Krt10^tm1Der/Krt10^+ Tg(KRT14-cre/PGR)1Der/0	involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR	MGI:2652794

Genotype
MGI:2652793

cn1

• Allelic Composition: Krt10^tm1Der/Krt10^tm1Der; Tg(KRT14-cre/PGR)1Der/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:82300 )

• animals die shortly after birth

integument

abnormal epidermis stratum spinosum morphology ( J:82300 )

• complete disintegration of the stratum spinosum

blistering ( J:82300 )

• severe blistering and erosion of the skin

skin lesions ( J:82300 )

Genotype
MGI:2652794

cn2

• Allelic Composition: Krt10^tm1Der/Krt10⁺; Tg(KRT14-cre/PGR)1Der/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR

integument

hyperkeratosis ( J:82300 )

• paws exhbit epidermal hyperkeratosis after onset of hair growth; hyperkeratosis persisted 6 months after initial RU486 treatment

blistering ( J:82300 )

• blisters develop after 3-5 topical treatments with RU486

scaly skin ( J:82300 )

• animals develop mild scaling