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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Apex1tm1Ecf
targeted mutation 1, Errol C Friedberg
MGI:2652193
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Apex1tm1Ecf/Apex1tm1Ecf either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6) MGI:3576492
ht2
Apex1tm1Ecf/Apex1+ either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6) MGI:2652224
cx3
Apex1tm1Ecf/Apex1+
Xpctm1Ecf/Xpctm1Ecf
involves: 129 MGI:2652241


Genotype
MGI:3576492
hm1
Allelic
Composition
Apex1tm1Ecf/Apex1tm1Ecf
Genetic
Background
either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apex1tm1Ecf mutation (0 available); any Apex1 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• embryos undetected at E7.5
• maternal antioxidant-enriched diet did not rescue lethality or increase the life expectancey of the embryos




Genotype
MGI:2652224
ht2
Allelic
Composition
Apex1tm1Ecf/Apex1+
Genetic
Background
either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apex1tm1Ecf mutation (0 available); any Apex1 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer offspring than expected by Mendelian ratios, reduction was not statistically significant
• maternal antioxidant-enriched diet increased embryonic survival

cellular
• sensitivity to inducers of oxygen-mediated DNA damage
• resistant to cell death induced by UV radiation
• increased sensitivity to oxidative stress
• elevated levels of oxidative markers in serum
• antioxidant-enriched diet restores serum oxidative marker levels to those of wild-type

neoplasm
• 25% developed microscopic tumors

immune system

cardiovascular system
• myocardial fibrosis




Genotype
MGI:2652241
cx3
Allelic
Composition
Apex1tm1Ecf/Apex1+
Xpctm1Ecf/Xpctm1Ecf
Genetic
Background
involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apex1tm1Ecf mutation (0 available); any Apex1 mutation (16 available)
Xpctm1Ecf mutation (1 available); any Xpc mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• 16% developed microscopic tumors

cellular
• increased sensitivity to oxidative stress





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory