Analysis Tools
mortality/aging
|
• 76% survive beyond 6 weeks and 23% survive beyond 6 months
|
|
• heterozygous intercrosses produce 16% homozygous live-born
• 7% of homozygotes die withing the first postnatal day
|
nervous system
|
• E13 olfactory epithelium has lower levels of olfactory receptor neuron apoptosis than normal although this is normal by 4 days of age
|
|
• E13 olfactory epithelium neuronal layer is thicker than normal
|
hydrocephaly
(
J:90572
)
|
• olfactory bulbs vary widely in size and often have a dramatically abnormal shape with hydrocephaly accompanying the most aberrent bulb shape
|
|
• at 4 days of age olfactory bulbs are normal in size and shape but have increased tyrosine hydroxylase expression in a subpopulation of periglomerular neurons
|
taste/olfaction
|
• E13 olfactory epithelium neuronal layer is thicker than normal
|
respiratory system
|
• E13 olfactory epithelium neuronal layer is thicker than normal
|
craniofacial
|
• E13 olfactory epithelium neuronal layer is thicker than normal
|
cellular
|
• E13 olfactory epithelium has lower levels of olfactory receptor neuron apoptosis than normal although this is normal by 4 days of age
|
growth/size/body
|
• E13 olfactory epithelium neuronal layer is thicker than normal
|
