Phenotypes associated with this allele

• Allele Symbol: Tph2⁺
• Allele Name: wild type
• Allele ID: MGI:2651812
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Tph2^em1(IMPC)Mbp/Tph2^+	C57BL/6N-Tph2^em1(IMPC)Mbp/MbpMmucd	MGI:7267114
ht2	Tph2^tm1Mca/Tph2^+	involves: 129S6/SvEvTac * C57BL/6J	MGI:3801151

Genotype
MGI:7267114

ht1

• Allelic Composition: Tph2^em1(IMPC)Mbp/Tph2⁺
• Genetic Background: C57BL/6N-Tph2^em1(IMPC)Mbp/MbpMmucd

Data Sources

IMPC Data for Tph2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

no spontaneous movement ( J:211773 )

IMPC - UCD

cardiovascular system

abnormal retina vasculature morphology ( J:211773 )

♀

IMPC - UCD

abnormal placenta vasculature ( J:211773 )

IMPC - UCD

embryo

abnormal placenta morphology ( J:211773 )

IMPC - UCD

abnormal placenta vasculature ( J:211773 )

IMPC - UCD

endocrine/exocrine glands

abnormal testis morphology ( J:211773 )

♂

IMPC - UCD

enlarged testis ( J:211773 )

♂

IMPC - UCD

growth/size/body

enlarged kidney ( J:211773 )

♀

IMPC - UCD

integument

abnormal skin morphology ( J:211773 )

♀

IMPC - UCD

liver/biliary system

abnormal liver morphology ( J:211773 )

♀

IMPC - UCD

small liver ( J:211773 )

♀

IMPC - UCD

nervous system

abnormal brain morphology ( J:211773 )

♀

IMPC - UCD

increased brain size ( J:211773 )

♀

IMPC - UCD

increased prepulse inhibition ( J:211773 )

IMPC - UCD

renal/urinary system

abnormal kidney morphology ( J:211773 )

♀

IMPC - UCD

enlarged kidney ( J:211773 )

♀

IMPC - UCD

reproductive system

abnormal testis morphology ( J:211773 )

♂

IMPC - UCD

enlarged testis ( J:211773 )

♂

IMPC - UCD

vision/eye

abnormal eye morphology ( J:211773 )

♀

IMPC - UCD

abnormal retina vasculature morphology ( J:211773 )

♀

IMPC - UCD

persistence of hyaloid vascular system ( J:211773 )

IMPC - UCD

Genotype
MGI:3801151

ht2

• Allelic Composition: Tph2^tm1Mca/Tph2⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

homeostasis/metabolism

decreased serotonin level ( J:131619 )

• 40% reduction in brain 5-HT production

behavior/neurological

increased aggression towards male mice ( J:131619 )

• although males do not exhibit increased attacks against a non-aggressive male in a test of social interaction, they do show an increase in threatening postures

decreased coping response ( J:131619 )

• immobility times in the tail suspension test are prolonged

increased anxiety-related response ( J:131619 )

• in the dark-light emergence test, mutants display longer latencies to cross to the lighted compartment and reduced activity in the lighted compartment