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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gpx2tm2Coh
targeted mutation 2, City of Hope, Beckman Research Institute
MGI:2651587
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gpx2tm2Coh/Gpx2tm2Coh involves: 129S1/Sv * C57BL/6 MGI:2652734
cx2
 		Gpx1tm1Ysh/Gpx1tm1Ysh
Gpx2tm2Coh/Gpx2tm2Coh 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:2652736
cx3
 		Gpx1tm1Ysh/Gpx1tm1Ysh
Gpx2tm2Coh/Gpx2+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:2652737
cx4
 		Gpx1tm1Ysh/Gpx1+
Gpx2tm2Coh/Gpx2tm2Coh 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:2652741


Genotype
MGI:2652734
hm1
Allelic
Composition		 Gpx2tm2Coh/Gpx2tm2Coh
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpx2tm2Coh mutation (0 available); any Gpx2 mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
digestive/alimentary phenotype ( J:63988 )
N
• no differences from wild-type in the sensitivity of the jejenum or ileum to gamma-irradiation




Genotype
MGI:2652736
cx2
Allelic
Composition		 Gpx1tm1Ysh/Gpx1tm1Ysh
Gpx2tm2Coh/Gpx2tm2Coh
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpx1tm1Ysh mutation (2 available); any Gpx1 mutation (19 available)
Gpx2tm2Coh mutation (0 available); any Gpx2 mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:71506 )
• 40% die or were euthanized due to poor health between 20-36 days of age

growth/size/body
decreased body weight ( J:71506 )
• gain weight more slowly or stop gaining weight completely starting around 16 days of age, however food intake is normal
cachexia ( J:71506 )
postnatal growth retardation ( J:71506 )
• onset of growth retardation is between 16 and 26 days of age

digestive/alimentary system
crypts of Lieberkuhn abscesses ( J:71506 )
• crypt abscesses are prevalent in the ileum, colon, and rectum
intestinal edema ( J:71506 )
• edematous colons
abnormal digestive system physiology ( J:71506 )
• anal mucus discharge
intestinal inflammation ( J:71506 )
• intestinal inflammation progresses from distal to proximal bowel in most homozygotes
colitis ( J:71506 )
• inflammation is limited to the mucosa
• 11 of 12 have distal colon colitis as early as 11 days of age
• 3 of 12 showed proximal colon colitis at 11-14 days of age
• most 15 day or older homozygotes have both distal and proximal colon inflammation
small intestinal inflammation ( J:71506 )
• severe inflammation of the ileum, but not jejunum or stomach , with inflammation limited to the mucosa

homeostasis/metabolism
intestinal edema ( J:71506 )
• edematous colons
decreased body temperature ( J:71506 )
• hypothermic under normal housing conditions and become even more hypothermic after being housed in metabolic cages (rest on grids without bedding for 24 hrs)
abnormal enzyme/coenzyme level ( J:71506 )
• higher levels of lipid hydroperoxide in the ileum and colon, but not jejunum
abnormal enzyme/coenzyme activity ( J:71506 )
• myeloperoxidase activity is increased in colonic mucosa

endocrine/exocrine glands
crypts of Lieberkuhn abscesses ( J:71506 )
• crypt abscesses are prevalent in the ileum, colon, and rectum

immune system
intestinal inflammation ( J:71506 )
• intestinal inflammation progresses from distal to proximal bowel in most homozygotes
colitis ( J:71506 )
• inflammation is limited to the mucosa
• 11 of 12 have distal colon colitis as early as 11 days of age
• 3 of 12 showed proximal colon colitis at 11-14 days of age
• most 15 day or older homozygotes have both distal and proximal colon inflammation
small intestinal inflammation ( J:71506 )
• severe inflammation of the ileum, but not jejunum or stomach , with inflammation limited to the mucosa

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
inflammatory bowel disease DOID:0050589 OMIM:PS266600
 J:71506




Genotype
MGI:2652737
cx3
Allelic
Composition		 Gpx1tm1Ysh/Gpx1tm1Ysh
Gpx2tm2Coh/Gpx2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpx1tm1Ysh mutation (2 available); any Gpx1 mutation (19 available)
Gpx2tm2Coh mutation (0 available); any Gpx2 mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
diarrhea ( J:71506 )
• seen in 10% of mice, however do not exhibit premature death
intestinal inflammation ( J:71506 )
• seen in 16% of mice

immune system
intestinal inflammation ( J:71506 )
• seen in 16% of mice




Genotype
MGI:2652741
cx4
Allelic
Composition		 Gpx1tm1Ysh/Gpx1+
Gpx2tm2Coh/Gpx2tm2Coh
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpx1tm1Ysh mutation (2 available); any Gpx1 mutation (19 available)
Gpx2tm2Coh mutation (0 available); any Gpx2 mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:71506 )
• 10% mortality before 35 days of age, however do not exhibit cachexia

digestive/alimentary system
perianal ulcer ( J:71506 )
• seen in 17% of mice
diarrhea ( J:71506 )
• seen in 17% of mice
intestinal inflammation ( J:71506 )
• seen in 50% of mice

immune system
intestinal inflammation ( J:71506 )
• seen in 50% of mice

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
inflammatory bowel disease DOID:0050589 OMIM:PS266600
 J:71506




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/21/2024
MGI 6.23 		The Jackson Laboratory