All Phenotypes Cul3<tm1Jro> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cul3^tm1Jro
targeted mutation 1, James M Roberts
MGI:2651546

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cul3^tm1Jro/Cul3^tm1Jro	involves: 129S4/SvJaeSor * C57BL/6J	MGI:2664729
ht2	Cul3^tm1Jro/Cul3⁺	involves: 129S4/SvJaeSor	MGI:3714760
ht3	Cul3^tm1Jdsr/Cul3^tm1Jro	involves: 129S4/SvJaeSor * C57BL/6 * SJL	MGI:3714757
ht4	Cul3^tm1.1Jdsr/Cul3^tm1Jro	involves: 129S4/SvJaeSor * C57BL/6 * SJL	MGI:3714758

Allelic Composition	Cul3^tm1Jro/Cul3^tm1Jro
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cul3^tm1Jro mutation (0 available); any Cul3 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:57761 )

• in embryos after E7.5, yolk sacs contained partially degenerating or fully resorbed embryos

embryo

abnormal gastrulation ( J:57761 )

• abnormal gastrulation with no clear evidence of embryonic mesoderm and endoderm

decreased embryo size ( J:57761 )

• embryos were substantially smaller than wild-type embryos (E6.5)

abnormal trophectoderm morphology ( J:57761 )

• abnormally developed trophectoderm

abnormal trophoblast giant cell morphology ( J:57761 )

• trophoblast cells have small nucleii; despite high levels of nuclear cyclin E in these cells, no S-phase cells were detected

absent amnion ( J:57761 )

abnormal extraembryonic ectoderm morphology ( J:57761 )

• greatly elevated frequency of cells in S-phase

disorganized extraembryonic tissue ( J:57761 )

• absence of the extraembryonic cavities

growth/size/body

decreased embryo size ( J:57761 )

• embryos were substantially smaller than wild-type embryos (E6.5)

Allelic Composition	Cul3^tm1Jro/Cul3⁺
Genetic Background	involves: 129S4/SvJaeSor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cul3^tm1Jro mutation (0 available); any Cul3 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell cycle ( J:122228 )

• mouse embryonic fibroblast cultures have 26% of cells in S phase compared to 15% in wild-type

Allelic Composition	Cul3^tm1Jdsr/Cul3^tm1Jro
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cul3^tm1Jdsr mutation (1 available); any Cul3 mutation (50 available)
Cul3^tm1Jro mutation (0 available); any Cul3 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:122228 )

• no mice are born

Allelic Composition	Cul3^tm1.1Jdsr/Cul3^tm1Jro
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cul3^tm1.1Jdsr mutation (0 available); any Cul3 mutation (50 available)
Cul3^tm1Jro mutation (0 available); any Cul3 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:122228 )

• no mice are born

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