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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Atp1a2tm2Ling
targeted mutation 2, Jerry B Lingrel
MGI:2451291
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Atp1a2tm2Ling/Atp1a2tm2Ling involves: 129P2/OlaHsd * C57BL/6 * Black Swiss MGI:2451295
ht2
 		Atp1a2tm2Ling/Atp1a2+ involves: 129P2/OlaHsd MGI:3694085
ht3
 		Atp1a2tm2Ling/Atp1a2+ involves: 129P2/OlaHsd * Black Swiss MGI:3697483
ht4
 		Atp1a2tm2Ling/Atp1a2+ involves: 129P2/OlaHsd * C57BL/6 * Black Swiss MGI:2451298


Genotype
MGI:2451295
hm1
Allelic
Composition		 Atp1a2tm2Ling/Atp1a2tm2Ling
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp1a2tm2Ling mutation (0 available); any Atp1a2 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:55191 )
• homozygotes are born at normal frequency but do not survive first day of life




Genotype
MGI:3694085
ht2
Allelic
Composition		 Atp1a2tm2Ling/Atp1a2+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp1a2tm2Ling mutation (0 available); any Atp1a2 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
abnormal muscle contractility ( J:114415 )
• in isometric measurements of isolated EDL muscle, more force is produced at any given voltage, and has higher force is at supramaximal voltage compared to wild-type; peak tetanic force is 384 mN/sq. mm compared to 297 mN/sq. mm in wild-type
• rate of force development in tetanic contraction is significantly increased compared to wild-type
• EDL twitch force is 34% higher than that produced by wild-type
• constant for fatigue is similar to wild-type




Genotype
MGI:3697483
ht3
Allelic
Composition		 Atp1a2tm2Ling/Atp1a2+
Genetic
Background		 involves: 129P2/OlaHsd * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp1a2tm2Ling mutation (0 available); any Atp1a2 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal spatial learning ( J:117414 )
• increased latency to find the platform in a Morris water maze
increased anxiety-related response ( J:117414 )
• fewer entries into the open arms and less time spent in the open quadrants in an elevated zero maze
• less time spent in the center and more time spent in the corners of an open field and reduced movement in the first time period after being placed in an open field

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:117414 )
N
• circulating levels of corticosterone, norepinephrine, dopamine, serotonin, and their metabolites are all similar to wild-type mice




Genotype
MGI:2451298
ht4
Allelic
Composition		 Atp1a2tm2Ling/Atp1a2+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp1a2tm2Ling mutation (0 available); any Atp1a2 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased cardiac muscle contractility ( J:55191 )
• hearts are hypercontractile

muscle
decreased cardiac muscle contractility ( J:55191 )
• hearts are hypercontractile




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory