Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp1a1tm1Ling mutation
(0 available);
any
Atp1a1 mutation
(59 available)
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mortality/aging
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• no homozygous offspring are observed
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Allelic Composition |
Atp1a1tm1Ling/Atp1a1+
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Genetic Background |
involves: 129P2/OlaHsd |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp1a1tm1Ling mutation
(0 available);
any
Atp1a1 mutation
(59 available)
|
|
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muscle
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• peak tetanic force produced by extensor digitorum longus (EDL) muscle at supramaximal stimulation is ~240 mN/sq. mm compared to 297 mN/sq. mm in wild-type
• EDL muscle produces similar twitch force to wild-type muscle
• contractility of mutant muscle is increased with ouabain inhibition of Atp1a2
• constant for fatigue is similar to wild-type
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Allelic Composition |
Atp1a1tm1Ling/Atp1a1+
|
|
Genetic Background |
involves: 129P2/OlaHsd * Black Swiss |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp1a1tm1Ling mutation
(0 available);
any
Atp1a1 mutation
(59 available)
|
|
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behavior/neurological
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• increase in peak activity elicited by methamphetamine and prolonged habituation time
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• increased swimming speed during hidden platform training in a Morris water maze; however, latency to find the platform is not significantly different from wild-type
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homeostasis/metabolism
Allelic Composition |
Atp1a1tm1Ling/Atp1a1+
|
|
Genetic Background |
involves: 129P2/OlaHsd * C57BL/6 * Black Swiss |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp1a1tm1Ling mutation
(0 available);
any
Atp1a1 mutation
(59 available)
|
|
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cardiovascular system
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• hearts are hypocontractile
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muscle
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• hearts are hypocontractile
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