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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gemin2tm1Msd
targeted mutation 1, Michael Sendtner
MGI:2451054
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gemin2tm1Msd/Gemin2tm1Msd involves: 129P2/OlaHsd * C57BL/6 MGI:2451056
cx2
 		Gemin2tm1Msd/Gemin2+
Smn1tm1Msd/Smn1+ 		involves: 129P2/OlaHsd * C57BL/6 * MF1 MGI:2451057


Genotype
MGI:2451056
hm1
Allelic
Composition		 Gemin2tm1Msd/Gemin2tm1Msd
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gemin2tm1Msd mutation (0 available); any Gemin2 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:2451057
cx2
Allelic
Composition		 Gemin2tm1Msd/Gemin2+
Smn1tm1Msd/Smn1+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * MF1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gemin2tm1Msd mutation (0 available); any Gemin2 mutation (10 available)
Smn1tm1Msd mutation (37 available); any Smn1 mutation (87 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased motor neuron number ( J:81784 )
• number of lumbar motoneurons reduced by 34% at 5 months of age
• much less and non significant degeneration of facial motoneurons




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory