All Phenotypes Gemin2<tm1Msd> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gemin2^tm1Msd
targeted mutation 1, Michael Sendtner
MGI:2451054

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gemin2^tm1Msd/Gemin2^tm1Msd	involves: 129P2/OlaHsd * C57BL/6	MGI:2451056
cx2	Gemin2^tm1Msd/Gemin2⁺ Smn1^tm1Msd/Smn1⁺	involves: 129P2/OlaHsd * C57BL/6 * MF1	MGI:2451057

Allelic Composition	Gemin2^tm1Msd/Gemin2^tm1Msd
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gemin2^tm1Msd mutation (0 available); any Gemin2 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:81784 )

• during or shortly after implantation

Allelic Composition	Gemin2^tm1Msd/Gemin2⁺ Smn1^tm1Msd/Smn1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * MF1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gemin2^tm1Msd mutation (0 available); any Gemin2 mutation (10 available)
Smn1^tm1Msd mutation (37 available); any Smn1 mutation (86 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased motor neuron number ( J:81784 )

• number of lumbar motoneurons reduced by 34% at 5 months of age

• much less and non significant degeneration of facial motoneurons

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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