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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		S100a9tm1Nck
targeted mutation 1, Wolfgang Nacken
MGI:2450165
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		S100a9tm1Nck/S100a9tm1Nck B6.129P2-S100a9tm1Nck MGI:3758614
hm2
 		S100a9tm1Nck/S100a9tm1Nck involves: 129P2/OlaHsd * C57BL/6 MGI:3758615
cx3
 		Krt1tm1Tmm/Krt1tm1Tmm
S100a9tm1Nck/S100a9tm1Nck 		involves: 129P2/OlaHsd * C57BL/6 MGI:5509366


Genotype
MGI:3758614
hm1
Allelic
Composition		 S100a9tm1Nck/S100a9tm1Nck
Genetic
Background		 B6.129P2-S100a9tm1Nck
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
S100a9tm1Nck mutation (0 available); any S100a9 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to bacterial infection induced morbidity/mortality ( J:125179 )
• mice exhibit higher survival rates than wild-type mice when infected with 104 colony forming units of Escherichia coli

immune system
decreased circulating tumor necrosis factor level ( J:125179 )
• 20 minutes after exposure to LPS-galactosamine, serum TNF-alpha levels are reduced more than 20-fold relative to similarly treated wild-type mice
decreased susceptibility to endotoxin shock ( J:125179 )
• following exposure to LPS-galactosamine, mice are less severely affected and survive longer than similarly treated wild-type mice
• mice fail to respond to LPS stimulation as determined by gene expression
decreased susceptibility to bacterial infection induced morbidity/mortality ( J:125179 )
• mice exhibit higher survival rates than wild-type mice when infected with 104 colony forming units of Escherichia coli
decreased susceptibility to fungal infection ( J:209808 )
• mice inoculated with Candida albicans exhibit a reduction in vaginal fungal burden compared to wild-type mice, however polymorphonuclear neutrophil migration to the vagina is similar to levels in wild-type mice

homeostasis/metabolism
decreased circulating tumor necrosis factor level ( J:125179 )
• 20 minutes after exposure to LPS-galactosamine, serum TNF-alpha levels are reduced more than 20-fold relative to similarly treated wild-type mice




Genotype
MGI:3758615
hm2
Allelic
Composition		 S100a9tm1Nck/S100a9tm1Nck
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
S100a9tm1Nck mutation (0 available); any S100a9 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal cellular extravasation ( J:81642 )
• spontaneous migration of neutrophils in a in vitro transendothelial migration assay is increased relative to wild-type cells for 13.5% of neutrophils
• IL-8- and leukotriene B4- stimulated neutrophils in a in vitro transendothelial migration assay are only increased by 2.5- and 2.3-fold, respectively, compared to 3.8- and 6.1-fold, respectively, in wild-type cells
• however, polymorphonuclear neutrophil emigration into tissue is normal whether stimulated by IL-8 or thioglycolate

cellular
abnormal cellular extravasation ( J:81642 )
• spontaneous migration of neutrophils in a in vitro transendothelial migration assay is increased relative to wild-type cells for 13.5% of neutrophils
• IL-8- and leukotriene B4- stimulated neutrophils in a in vitro transendothelial migration assay are only increased by 2.5- and 2.3-fold, respectively, compared to 3.8- and 6.1-fold, respectively, in wild-type cells
• however, polymorphonuclear neutrophil emigration into tissue is normal whether stimulated by IL-8 or thioglycolate

hematopoietic system
abnormal cellular extravasation ( J:81642 )
• spontaneous migration of neutrophils in a in vitro transendothelial migration assay is increased relative to wild-type cells for 13.5% of neutrophils
• IL-8- and leukotriene B4- stimulated neutrophils in a in vitro transendothelial migration assay are only increased by 2.5- and 2.3-fold, respectively, compared to 3.8- and 6.1-fold, respectively, in wild-type cells
• however, polymorphonuclear neutrophil emigration into tissue is normal whether stimulated by IL-8 or thioglycolate




Genotype
MGI:5509366
cx3
Allelic
Composition		 Krt1tm1Tmm/Krt1tm1Tmm
S100a9tm1Nck/S100a9tm1Nck
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krt1tm1Tmm mutation (0 available); any Krt1 mutation (67 available)
S100a9tm1Nck mutation (0 available); any S100a9 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality, complete penetrance ( J:200244 )
• no survivors are generated




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory