Phenotypes associated with this allele

• Allele Symbol: Mtnr1b^tm1Drw
• Allele Name: targeted mutation 1, David R Weaver
• Allele ID: MGI:2450159
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mtnr1b^tm1Drw/Mtnr1b^tm1Drw	C3.129S4-Mtnr1b^tm1Drw	MGI:3574937

Genotype
MGI:3574937

hm1

• Allelic Composition: Mtnr1b^tm1Drw/Mtnr1b^tm1Drw
• Genetic Background: C3.129S4-Mtnr1b^tm1Drw

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:81644 )

• in particular, circadian function appears normal

behavior/neurological

abnormal long-term spatial reference memory ( J:105804 )

• transfer latentcies to enter the closed arm of an elevated plus maze is not changed in mutant mice, while is reduced by the second day in controls

nervous system

impaired synaptic plasticity ( J:105804 )

reduced long-term potentiation ( J:105804 )

• theta burst stimulation induced robust and stable long-term potentiation in controls that was smaller and decremental in slices from knockout mice