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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zfxtm1Dcp
targeted mutation 1, David C Page
MGI:2450147
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Zfxtm1Dcp/Zfxtm1Dcp involves: 129S4/SvJae * BALB/c MGI:2653291
hm2
 		Zfxtm1Dcp/Zfxtm1Dcp involves: 129S4/SvJae * C57BL/6J MGI:2653292
ht3
 		Zfxtm1Dcp/Zfx+ involves: 129S4/SvJae * BALB/c MGI:2653290
ht4
 		Zfxtm1Dcp/Zfx+ involves: 129S4/SvJae * C57BL/6J MGI:2653289
ot5
 		Zfxtm1Dcp/Y involves: 129S4/SvJae * BALB/c MGI:2653287
ot6
 		Zfxtm1Dcp/Y involves: 129S4/SvJae * C57BL/6J MGI:2653288


Genotype
MGI:2653291
hm1
Allelic
Composition		 Zfxtm1Dcp/Zfxtm1Dcp
Genetic
Background		 involves: 129S4/SvJae * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfxtm1Dcp mutation (0 available); any Zfx mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:41131 )
• approximately 90% died in the neonatal period

embryo
decreased embryo size ( J:41131 )
• 20% reduction in body size relative to heterozygous female embryos

endocrine/exocrine glands

growth/size/body
decreased embryo size ( J:41131 )
• 20% reduction in body size relative to heterozygous female embryos
decreased body weight ( J:41131 )
• 20% to 30% reduction in body size relative to heterozygous females
• growth disturbance originates prior to E12.5

reproductive system
decreased oocyte number ( J:41131 )
• oocyte deficit exists at 4-5 days after birth therefore independent of reproductive cycling
• oocyte deficit is one eighth the number in +/+ females
decreased primordial germ cell number ( J:41131 )
• reduced number of primordial germ cells at E11.5
reduced female fertility ( J:41131 )
• shortened reproductive lifespan
• only 31% of females mated produced litters
• litter size averaged 4 compared to 6 produced by +/- females

cellular
decreased oocyte number ( J:41131 )
• oocyte deficit exists at 4-5 days after birth therefore independent of reproductive cycling
• oocyte deficit is one eighth the number in +/+ females
decreased primordial germ cell number ( J:41131 )
• reduced number of primordial germ cells at E11.5




Genotype
MGI:2653292
hm2
Allelic
Composition		 Zfxtm1Dcp/Zfxtm1Dcp
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfxtm1Dcp mutation (0 available); any Zfx mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

growth/size/body
abnormal postnatal growth/weight/body size ( J:41131 )
abnormal embryonic growth/weight/body size ( J:41131 )

reproductive system




Genotype
MGI:2653290
ht3
Allelic
Composition		 Zfxtm1Dcp/Zfx+
Genetic
Background		 involves: 129S4/SvJae * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfxtm1Dcp mutation (0 available); any Zfx mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:41131 )
• approximately 50% died in the neonatal period

reproductive system
decreased oocyte number ( J:41131 )
• at 4-5 days after birth total is signficantly less than found in +/+ littermates

cellular
decreased oocyte number ( J:41131 )
• at 4-5 days after birth total is signficantly less than found in +/+ littermates




Genotype
MGI:2653289
ht4
Allelic
Composition		 Zfxtm1Dcp/Zfx+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfxtm1Dcp mutation (0 available); any Zfx mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:41131 )
• approximately 50% of the offspring died prior to weaning




Genotype
MGI:2653287
ot5
Allelic
Composition		 Zfxtm1Dcp/Y
Genetic
Background		 involves: 129S4/SvJae * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfxtm1Dcp mutation (0 available); any Zfx mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:41131 )
• approximately 90% died in the neonatal period

embryo
decreased embryo size ( J:41131 )
• 20% reduction in body size relative to wild-type male embryos

growth/size/body
decreased embryo size ( J:41131 )
• 20% reduction in body size relative to wild-type male embryos
decreased body weight ( J:41131 )
• 20% to 25% reduction in body size relative to wild-type males
• growth disturbance originates prior to E12.5

reproductive system
oligozoospermia ( J:41131 )
• sperm counts were half those of wild-type
decreased primordial germ cell number ( J:41131 )
• reduced number of primordial germ cells at E11.5

cellular
oligozoospermia ( J:41131 )
• sperm counts were half those of wild-type
decreased primordial germ cell number ( J:41131 )
• reduced number of primordial germ cells at E11.5




Genotype
MGI:2653288
ot6
Allelic
Composition		 Zfxtm1Dcp/Y
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfxtm1Dcp mutation (0 available); any Zfx mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:41131 )
• mice died prior to weaning




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory