All Phenotypes Apc<tm2Mmt> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Apc^tm2Mmt
targeted mutation 2, Makoto M Taketo
MGI:2449941

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Apc^tm2Mmt/Apc^tm2Mmt	involves: 129X1/SvJ	MGI:3811533
ht2	Apc^tm2Mmt/Apc⁺	involves: 129X1/SvJ	MGI:3811534
ht3	Apc^tm2Mmt/Apc^tm3Mmt	involves: 129X1/SvJ * C57BL/6N	MGI:3811543

Allelic Composition	Apc^tm2Mmt/Apc^tm2Mmt
Genetic Background	involves: 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm2Mmt mutation (0 available); any Apc mutation (154 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality ( J:81402 )

Allelic Composition	Apc^tm2Mmt/Apc⁺
Genetic Background	involves: 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm2Mmt mutation (0 available); any Apc mutation (154 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased intestinal adenoma incidence ( J:81402 )

digestive/alimentary system

increased intestinal adenoma incidence ( J:81402 )

Allelic Composition	Apc^tm2Mmt/Apc^tm3Mmt
Genetic Background	involves: 129X1/SvJ * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^tm2Mmt mutation (0 available); any Apc mutation (154 available)
Apc^tm3Mmt mutation (0 available); any Apc mutation (154 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal embryonic tissue morphology ( J:81402 )

• at E7.5, the anterior embryonic region is protruding from the yolk sac; more prominent at E8.5

abnormal embryonic epiblast morphology ( J:81402 )

• at E6.5, embryonic ectoderm cells remain only in the distal region

• however, visceral endoderm develops normally

abnormal egg cylinder morphology ( J:81402 )

• at E6.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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