Phenotypes associated with this allele

• Allele Symbol: Pax6^tm1Lan
• Allele Name: targeted mutation 1, Richard A Lang
• Allele ID: MGI:2449854
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pax6^tm1Lan/Pax6^tm1Lan	involves: 129S1/Sv * 129X1/SvJ	MGI:3759848
ht2	Pax6^tm1Lan/Pax6^+	involves: 129S1/Sv * 129X1/SvJ	MGI:3759850

Genotype
MGI:3759848

hm1

• Allelic Composition: Pax6^tm1Lan/Pax6^tm1Lan
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal lens morphology ( J:73524 )

• by E17.5, lens size difference compared to wild-type is reduced relative to earlier embryonic ages, but lens stalk persists

abnormal lens vesicle development ( J:73524 )

• by E10.5, lens pit is significantly smaller than wild-type, whereas at E11.5, lens vesicle is still connected to surface ectoderm and remains small

abnormal optic placode morphology ( J:73524 )

• at E9.5, regional reduction in placodal thickness is observed with surface ectoderm apposed to optic vesicle being markedly thinner; proportion of proliferating cells in this region is significantly different from wild-type

abnormal lens epithelium morphology ( J:73524 )

• lens epithelial layer remains attached to surface ectoderm (prospective corneal epithelium)

abnormal lens fiber morphology ( J:73524 )

• lens fiber cell differentiation is delayed compared to wild-type

Genotype
MGI:3759850

ht2

• Allelic Composition: Pax6^tm1Lan/Pax6⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

vision/eye

abnormal lens vesicle development ( J:73524 )

• by E10.5, lens pit is intermediate in size between homozygotes and wild-type; at E11.5, lens separation defect is less severe than in homozygotes

abnormal optic placode morphology ( J:73524 )

• at E9.5, regional reduction in placodal thickness is observed with surface ectoderm apposed to optic vesicle being markedly thinner