Phenotypes associated with this allele

• Allele Symbol: Tg(Col2a1-Nppc)1Yog
• Allele Name: transgene insertion 1, Yoshihiro Ogawa
• Allele ID: MGI:2449705
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Nppc^tm1Yog/Nppc^tm1Yog Tg(Col2a1-Nppc)1Yog/0	either: 129X1/SvJ or (involves: 129 * C57BL/6J)	MGI:3522091
cx2	Nppc^lbab/Nppc^lbab Tg(Col2a1-Nppc)1Yog/0	involves: C57BL/6J * PL/J	MGI:7276255

Genotype
MGI:3522091

cx1

• Allelic Composition: Nppc^tm1Yog/Nppc^tm1Yog; Tg(Col2a1-Nppc)1Yog/0
• Genetic Background: either: 129X1/SvJ or (involves: 129 * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:75620 )

N • survival is improved to at least 20 weeks of age

skeleton

skeleton phenotype ( J:75620 )

N • skeleton is normal

Genotype
MGI:7276255

cx2

• Allelic Composition: Nppc^lbab/Nppc^lbab; Tg(Col2a1-Nppc)1Yog/0
• Genetic Background: involves: C57BL/6J * PL/J

growth/size/body

decreased body weight ( J:321139 )

• body weight is decreased until 3 weeks of age but then promptly increases to wild-type levels

decreased body length ( J:321139 )

• the nasoanal length is smaller at the first week after birth, however subsequently mice begin to grow and catch up with wild-type mice after 4 weeks of age

skeleton

skeleton phenotype ( J:321139 )

N • the impaired growth of bones formed through endochondral ossification seen in Nppc^lbab mice is partially recovered at 2 weeks of age and almost completely recovered by 10 weeks of age and the reduction in bone volume and trabecular thickness of humerus seen in single Nppc^lbab homozygotes is rescued

decreased width of hypertrophic chondrocyte zone ( J:321139 )

• the thinner hypertrophic chondrocyte layer is considerably recovered but not completely

• however, proliferative chondrocyte layer is normal and tibial growth plate thickness is normal at 10 weeks of age