Analysis Tools|
Allele Symbol Allele Name Allele ID |
Opn4tm1Skay targeted mutation 1, Steve A Kay MGI:2449695 |
||||||||||||||||||||||||
| Summary |
5 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• intrinsic inner retinal photosensitivity is absent
|
|
• intrinsic inner retinal photosensitivity is absent
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice exhibit a shorter than normal period when exposed to constant light
|
|
• mice exhibit an attenuated phase delay compared to in wild-type mice during phase shifting
• however, mice exhibit normal circadian behavior rhythms and light suppression of activity
|
|
• melanopsin+ retinal ganglion cells are absent
|
|
• melanopsin+ retinal ganglion cells are absent
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• unlike wild-type, mice fail to exhibit exhibit a 50% augmentation in pupillary light response (PLR) compared to pre-bright light PLR during a one minute dim blue light exposure after bright light exposure called photopotentiation
|
|
• unlike wild-type, mice fail to exhibit exhibit a 50% augmentation in pupillary light response (PLR) compared to pre-bright light PLR during a one minute dim blue light exposure after bright light exposure called photopotentiation
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• retinas exhibit normal photoentrainment to white light, photosensitivity to violet light and corneal photoentrainment
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• pupilary reflex is abolished
|
|
• mice lose their ability to photo-entrain their circadian rhythm and mice maintain equal activity during light and dark phases unlike in wild-type mice
|
|
• pupilary reflex is abolished
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 09/30/2025 MGI 6.24 |
|
|
|
||
