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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Opn4tm1Skay
targeted mutation 1, Steve A Kay
MGI:2449695
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Opn4tm1Skay/Opn4tm1Skay involves: 129S1/SvImJ MGI:3803315
hm2
 		Opn4tm1Skay/Opn4tm1Skay involves: 129S1/SvImJ * C57BL/6 MGI:3803118
hm3
 		Opn4tm1Skay/Opn4tm1Skay involves: 129S1/SvImJ * C57BL/6J MGI:3803324
cx4
 		Opn4tm1Skay/Opn4tm1Skay
Pde6brd1/Pde6brd1 		B6.Cg-Pde6brd1 Opn4tm1Skay MGI:5897205
cx5
 		Opn4tm1Skay/Opn4tm1Skay
Pde6brd1/Pde6brd1 		involves: 129S1/SvImJ * C57BL/6 MGI:3803117


Genotype
MGI:3803315
hm1
Allelic
Composition		 Opn4tm1Skay/Opn4tm1Skay
Genetic
Background		 involves: 129S1/SvImJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Opn4tm1Skay mutation (0 available); any Opn4 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
photosensitivity ( J:107606 )
• intrinsic inner retinal photosensitivity is absent

homeostasis/metabolism
photosensitivity ( J:107606 )
• intrinsic inner retinal photosensitivity is absent




Genotype
MGI:3803118
hm2
Allelic
Composition		 Opn4tm1Skay/Opn4tm1Skay
Genetic
Background		 involves: 129S1/SvImJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Opn4tm1Skay mutation (0 available); any Opn4 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
shortened circadian behavior period ( J:81501 )
• mice exhibit a shorter than normal period when exposed to constant light
abnormal circadian behavior phase ( J:81501 )
• mice exhibit an attenuated phase delay compared to in wild-type mice during phase shifting
• however, mice exhibit normal circadian behavior rhythms and light suppression of activity

vision/eye
abnormal retina ganglion cell morphology ( J:81501 )
• melanopsin+ retinal ganglion cells are absent

nervous system
abnormal retina ganglion cell morphology ( J:81501 )
• melanopsin+ retinal ganglion cells are absent




Genotype
MGI:3803324
hm3
Allelic
Composition		 Opn4tm1Skay/Opn4tm1Skay
Genetic
Background		 involves: 129S1/SvImJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Opn4tm1Skay mutation (0 available); any Opn4 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal pupillary reflex ( J:123259 )
• unlike wild-type, mice fail to exhibit exhibit a 50% augmentation in pupillary light response (PLR) compared to pre-bright light PLR during a one minute dim blue light exposure after bright light exposure called photopotentiation

vision/eye
abnormal pupillary reflex ( J:123259 )
• unlike wild-type, mice fail to exhibit exhibit a 50% augmentation in pupillary light response (PLR) compared to pre-bright light PLR during a one minute dim blue light exposure after bright light exposure called photopotentiation




Genotype
MGI:5897205
cx4
Allelic
Composition		 Opn4tm1Skay/Opn4tm1Skay
Pde6brd1/Pde6brd1
Genetic
Background		 B6.Cg-Pde6brd1 Opn4tm1Skay
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Opn4tm1Skay mutation (0 available); any Opn4 mutation (33 available)
Pde6brd1 mutation (41 available); any Pde6b mutation (119 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal eye physiology ( J:227078 )
• retinas exhibit normal photoentrainment to white light, photosensitivity to violet light and corneal photoentrainment




Genotype
MGI:3803117
cx5
Allelic
Composition		 Opn4tm1Skay/Opn4tm1Skay
Pde6brd1/Pde6brd1
Genetic
Background		 involves: 129S1/SvImJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Opn4tm1Skay mutation (0 available); any Opn4 mutation (33 available)
Pde6brd1 mutation (41 available); any Pde6b mutation (119 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
impaired pupillary reflex ( J:137151 )
• pupilary reflex is abolished
abnormal circardian behavior entrainment ( J:137151 )
• mice lose their ability to photo-entrain their circadian rhythm and mice maintain equal activity during light and dark phases unlike in wild-type mice

vision/eye
impaired pupillary reflex ( J:137151 )
• pupilary reflex is abolished




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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory