Phenotypes associated with this allele

• Allele Symbol: Tenm4^l7Rn3-3R
• Allele Name: mutation 3, Oak Ridge
• Allele ID: MGI:2449637
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tenm4^l7Rn3-3R/Tenm4^l7Rn3-3R	FRCH.Cg-Tenm4^l7Rn3-3R	MGI:3789294
hm2	Tenm4^l7Rn3-3R/Tenm4^l7Rn3-3R	involves: BALB/cRl * C3H/Rl * C57BL/10Rl	MGI:2449638
ht3	Tenm4^l7Rn3-3R/Tenm4^l7Rn3-6R	Not Specified	MGI:3789908

Genotype
MGI:3789294

hm1

• Allelic Composition: Tenm4^l7Rn3-3R/Tenm4^l7Rn3-3R
• Genetic Background: FRCH.Cg-Tenm4^l7Rn3-3R

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:96673 )

• mutant embryos die between E9.5 and E11.5, but undergo gastrulation, generate embryonic and extraembryonic mesoderm and establish an A-P axis

embryo

embryonic growth retardation ( J:96673 )

• developmental delay is noted by E7.5

open neural tube ( J:96673 )

• open head folds and kinky open neural tube

incomplete somite formation ( J:96673 )

• incomplete somitogenesis

growth/size/body

embryonic growth retardation ( J:96673 )

• developmental delay is noted by E7.5

nervous system

open neural tube ( J:96673 )

• open head folds and kinky open neural tube

Genotype
MGI:2449638

hm2

• Allelic Composition: Tenm4^l7Rn3-3R/Tenm4^l7Rn3-3R
• Genetic Background: involves: BALB/cRl * C3H/Rl * C57BL/10Rl

mortality/aging

prenatal lethality, complete penetrance ( J:54592 )

Genotype
MGI:3789908

ht3

• Allelic Composition: Tenm4^l7Rn3-3R/Tenm4^l7Rn3-6R
• Genetic Background: Not Specified

mortality/aging

mortality/aging ( J:96673 )

N • compound mutant animals are viable

skeleton

abnormal cervical axis morphology ( J:96673 )

• in compound mutant animals, an aberrant spinous process is observed in 60% of animals