All Phenotypes Hprt1<tm2(AGT)Sig> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hprt1^tm2(AGT)Sig
targeted mutation 2, Curt Sigmund
MGI:2449453

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hprt1^tm2(AGT)Sig/Hprt1^tm2(AGT)Sig	involves: 129P2/OlaHsd * C57BL/6J	MGI:3720727
cx2	Hprt1^tm2(AGT)Sig/Hprt1^tm2(AGT)Sig Tg(hAGT)2041Sig/?	involves: 129P2/OlaHsd * C57BL/6 * SJL/J	MGI:3720717
cx3	Hprt1^tm2(AGT)Sig/Y Tg(hAGT)2041Sig/?	involves: 129P2/OlaHsd * C57BL/6 * SJL/J	MGI:3720718
ot4	Hprt1^tm2(AGT)Sig/Y	involves: 129P2/OlaHsd * C57BL/6J	MGI:3720728

Allelic Composition	Hprt1^tm2(AGT)Sig/Hprt1^tm2(AGT)Sig
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1^tm2(AGT)Sig mutation (0 available); any Hprt1 mutation (1274 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

increased systemic arterial blood pressure ( J:81515 )

• after administration of human angiotensin protein, blood pressure is increased by 25.6+/-2.0 mmHg compared to control mice

Allelic Composition	Hprt1^tm2(AGT)Sig/Hprt1^tm2(AGT)Sig Tg(hAGT)2041Sig/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1^tm2(AGT)Sig mutation (0 available); any Hprt1 mutation (1274 available)
Tg(hAGT)2041Sig mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

increased heart weight ( J:81310 )

• females exhibit an increase in heart weight-to-body weight relative to controls

growth/size/body

increased heart weight ( J:81310 )

• females exhibit an increase in heart weight-to-body weight relative to controls

Allelic Composition	Hprt1^tm2(AGT)Sig/Y Tg(hAGT)2041Sig/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1^tm2(AGT)Sig mutation (0 available); any Hprt1 mutation (1274 available)
Tg(hAGT)2041Sig mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

increased systemic arterial blood pressure ( J:81310 )

• males exhibit an increase in blood pressure of 9.7+/-0.9 mmHg compared to control littermates

Allelic Composition	Hprt1^tm2(AGT)Sig/Y
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1^tm2(AGT)Sig mutation (0 available); any Hprt1 mutation (1274 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

increased systemic arterial blood pressure ( J:81515 )

• after administration of human angiotensin protein, blood pressure is increased by 25.6+/-2.0 mmHg compared to control mice

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