Phenotypes associated with this allele

• Allele Symbol: Fmn2^tm1Led
• Allele Name: targeted mutation 1, Philip Leder
• Allele ID: MGI:2448909
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fmn2^tm1Led/Fmn2^tm1Led	either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss)	MGI:2654511

Genotype
MGI:2654511

hm1

• Allelic Composition: Fmn2^tm1Led/Fmn2^tm1Led
• Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal oocyte morphology ( J:81246 )

♀ • meiotic incompetence in oocytes results in polyploid embryos

abnormal primary polar body morphology ( J:81246 )

♀ • mutant oocytes cannot correctly position the metaphase spindle during meiosis I and form the first polar body

abnormal female meiosis ( J:81246 )

♀ • homozygous females ovulate oocytes that fail to progress through metaphase I and to correctly position the metaphase I spindle at the cortex of the oocyte, resulting in the ovulation of oocytes that have not formed the first polar body

abnormal pregnancy ( J:81246 )

♀ • homozygous females mated to wild-type male exhibit recurrent pregnancy loss during early and mid-gestational stages of development

reduced female fertility ( J:81246 )

♀ • homozygous females rarely carry embryos to term and give birth

♀ • homozygous females mated with wild-type males contain a normal number of uterine decidua but most decidua contain grossly abnormal embryos

behavior/neurological

abnormal nursing ( J:81246 )

♀ • few pups that are born die from inadequate nursing as a result of a small litter size

cellular

abnormal oocyte morphology ( J:81246 )

♀ • meiotic incompetence in oocytes results in polyploid embryos

abnormal primary polar body morphology ( J:81246 )

♀ • mutant oocytes cannot correctly position the metaphase spindle during meiosis I and form the first polar body