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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mepetm1Tbrw
targeted mutation 1, Thomas A Brown
MGI:2448895
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mepetm1Tbrw/Mepetm1Tbrw involves: 129P2/OlaHsd * C57BL/6 MGI:3578992
ht2
Mepetm1Tbrw/Mepe+ involves: 129P2/OlaHsd * C57BL/6 MGI:3578993


Genotype
MGI:3578992
hm1
Allelic
Composition
Mepetm1Tbrw/Mepetm1Tbrw
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mepetm1Tbrw mutation (0 available); any Mepe mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Increased trabecular bone in 1 year old Mepetm1Tbrw/Mepe+ and Mepetm1Tbrw/Mepetm1Tbrw mice

hematopoietic system
• slight but non significant reduction in osteoclast surface and osteoclast number

skeleton
• slight but non significant reduction in osteoclast surface and osteoclast number
• increased amount of trabecular bone first noticeable at 4 months of age (50% increase in females, 32% increase in males)
• by 1 year of age males showed a 2-fold increase and females a 3 fold increase
• 10 month old males had a 2 fold increase in osteoblasts in the distal femur
• less aging associated bone loss
• no bone loss in year old males
• females with 15% bone loss at 1 year of age
• significant increase in the mineral apposition rate

immune system
• slight but non significant reduction in osteoclast surface and osteoclast number




Genotype
MGI:3578993
ht2
Allelic
Composition
Mepetm1Tbrw/Mepe+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mepetm1Tbrw mutation (0 available); any Mepe mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Increased trabecular bone in 1 year old Mepetm1Tbrw/Mepe+ and Mepetm1Tbrw/Mepetm1Tbrw mice

skeleton
• Increased amount of trabecular bone first noticeable at 4 months of age (32% increase in males)
• By 1 year of age males showed a 2 fold increase and females a 3 fold increase





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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory