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Allele Symbol Allele Name Allele ID |
Tg(BCL2/IGH)M23Tjd transgene insertion M23, Timothy J McDonnell MGI:2448740 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• plasmablastic lymphoma (PBL) in 20% of mice at age 17-18 months after chronic immunization with sheep red blood cells (SRBCs)
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• in 40% of mice at age 17-18 months after chronic immunization with sheep red blood cells (SRBCs)
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• modest increase in the number of splenic mononuclear cells in mice at 8-19 weeks of age compared to controls
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• modest enlargement at 20 weeks of age
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• extensive hyperplasia of the white pulp zone
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• increase in the percentage and absolute number of B cells in the spleen
• however, the absolute number of splenic T cells is similar to controls
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• expanded white pulp area, primarily containing B cells
• however, the mantle zone is normal, no red pulp invasion is seen, and the geographic distribution of B and T cells within the white pulp is similar to wild-type mice
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• prolonged survival of a subset (about 10% of the total number of cells) of B cells compared to control cells when cultured in DMEM supplemented with only 5% fetal calf serum
• this prolonged survival results in about a 500-fold survival advantage after 14 days in culture
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• in the para-aortic lymph node the medullary cords and interfollicular area are abnormal with expansion by infiltrates of mixed small and large cleaved follicular center cells, immunoblasts, and plasma cells
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• 2- to 3-fold enlargement of the mesenteric and para-aortic lymph nodes in mice over 15 weeks of age
• however, no enlargement of other regional or peripheral lymph nodes is seen in mice up to 25 weeks of age
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• modest increase in the number of splenic mononuclear cells in mice at 8-19 weeks of age compared to controls
|
|
• modest enlargement at 20 weeks of age
|
|
• extensive hyperplasia of the white pulp zone
|
|
• increase in the percentage and absolute number of B cells in the spleen
• however, the absolute number of splenic T cells is similar to controls
|
|
• expanded white pulp area, primarily containing B cells
• however, the mantle zone is normal, no red pulp invasion is seen, and the geographic distribution of B and T cells within the white pulp is similar to wild-type mice
|
|
• prolonged survival of a subset (about 10% of the total number of cells) of B cells compared to control cells when cultured in DMEM supplemented with only 5% fetal calf serum
• this prolonged survival results in about a 500-fold survival advantage after 14 days in culture
|
|
• modest increase in the number of splenic mononuclear cells in mice at 8-19 weeks of age compared to controls
|
|
• modest enlargement at 20 weeks of age
|
|
• extensive hyperplasia of the white pulp zone
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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