Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rgtm1Krf mutation
(0 available);
any
Il2rg mutation
(168 available)
Tg(BCL2/IGH)1Tjd mutation
(0 available)
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immune system
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• mice have about 10-fold fewer thymocytes compared to wild-type mice
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hematopoietic system
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• mice have about 10-fold fewer thymocytes compared to wild-type mice
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endocrine/exocrine glands
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• mice have about 10-fold fewer thymocytes compared to wild-type mice
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Allelic
Composition |
Tg(BCL2/IGH)1Tjd/?
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Genetic
Background |
involves: C3H/He * C57BL/6 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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immune system
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• modest increase in the number of splenic mononuclear cells in mice at 8-19 weeks of age compared to controls
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• modest enlargement at 20 weeks of age
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• extensive hyperplasia of the white pulp zone
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• increase in the percentage and absolute number of B cells in the spleen
• however, the absolute number of splenic T cells is similar to controls
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• expanded white pulp area, primarily containing B cells
• however, the mantle zone is normal, no red pulp invasion is seen, and the geographic distribution of B and T cells within the white pulp is similar to wild-type mice
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• prolonged survival of a subset (about 10% of the total number of cells) of B cells compared to control cells when cultured in DMEM supplemented with only 5% fetal calf serum
• this prolonged survival results in about a 500-fold survival advantage after 14 days in culture
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• in the para-aortic lymph node the medullary cords and interfollicular area are abnormal with expansion by infiltrates of mixed small and large cleaved follicular center cells, immunoblasts, and plasma cells
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• 2- to 3-fold enlargement of the mesenteric and para-aortic lymph nodes in mice over 15 weeks of age
• however, no enlargement of other regional or peripheral lymph nodes is seen in mice up to 25 weeks of age
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hematopoietic system
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• modest increase in the number of splenic mononuclear cells in mice at 8-19 weeks of age compared to controls
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• modest enlargement at 20 weeks of age
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• extensive hyperplasia of the white pulp zone
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• increase in the percentage and absolute number of B cells in the spleen
• however, the absolute number of splenic T cells is similar to controls
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|
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• expanded white pulp area, primarily containing B cells
• however, the mantle zone is normal, no red pulp invasion is seen, and the geographic distribution of B and T cells within the white pulp is similar to wild-type mice
|
|
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• prolonged survival of a subset (about 10% of the total number of cells) of B cells compared to control cells when cultured in DMEM supplemented with only 5% fetal calf serum
• this prolonged survival results in about a 500-fold survival advantage after 14 days in culture
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cellular
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• modest increase in the number of splenic mononuclear cells in mice at 8-19 weeks of age compared to controls
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growth/size/body
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• modest enlargement at 20 weeks of age
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• extensive hyperplasia of the white pulp zone
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Analysis Tools