About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rs1tmgc1
Tennessee Mouse Genome Consortium 1
MGI:2448640
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rs1tmgc1/Rs1tmgc1 involves: C3H/Rl * C57BL/6 MGI:2448896
cx2
 		Morq1AKR/J/Morq1AKR/J
Rs1tmgc1/Y 		B6.Cg-Rs1tmgc1 Morq1AKR/J MGI:3784608
cx3
 		Morq1AKR/J/Morq1AKR/J
Rs1tmgc1/Rs1tmgc1 		B6.Cg-Rs1tmgc1 Morq1AKR/J MGI:3784609
cx4
 		Morq1AKR/J/Morq1AKR/J
Rs1tmgc1/Y 		involves: AKR/J * C3H/Rl * C57BL/6JRn MGI:3784605
cx5
 		Morq1AKR/J/Morq1C57BL/6JRn
Rs1tmgc1/Y 		involves: AKR/J * C3H/Rl * C57BL/6JRn MGI:3784606
cx6
 		Morq1AKR/J/Morq1C3H/Rl
Rs1tmgc1/Y 		involves: AKR/J * C3H/Rl * C57BL/6JRn MGI:3784607


Genotype
MGI:2448896
hm1
Allelic
Composition		 Rs1tmgc1/Rs1tmgc1
Genetic
Background		 involves: C3H/Rl * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rs1tmgc1 mutation (0 available); any Rs1 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal ocular fundus morphology ( J:99982 )
• microflecks and streaks seen in all males and about 61% of females
• possibly due to the undulating pattern of the outer nuclear layer and the presence of rosettes
abnormal retina pigment epithelium morphology ( J:81149 )
• small patchy areas of RPE depigmentation and clumping
abnormal retina inner nuclear layer morphology ( J:99982 )
• layer split in some regions
abnormal retina outer nuclear layer morphology ( J:99982 )
• clusters of photoreceptor nuclei migrate into inner and sometimes outer segments of the photoreceptor by 10 weeks of age
• more prevalent at 18 months
abnormal retina outer plexiform layer morphology ( J:99982 )
• sometimes disrupted by cell bodies of inner and outer nuclear layers
• expanded into inner nuclear layer by 18 months of age
abnormal retina photoreceptor layer morphology ( J:99982 )
• considerably shortened by 18 months of age
abnormal photoreceptor inner segment morphology ( J:99982 )
• sometimes disrupted by presence of photoreceptor nuclei
abnormal photoreceptor outer segment morphology ( J:99982 )
• occasionally also affected by presence of photoreceptor nuclei
disorganized retina layers ( J:99982 )
• disrupted lamination of the retina
abnormal eye electrophysiology ( J:81149 , J:99982 )
(J:81149)
• reduced amplitude of a and b waves on electroretinograms, particularly at higher flash intensities (J:99982)

nervous system
abnormal photoreceptor inner segment morphology ( J:99982 )
• sometimes disrupted by presence of photoreceptor nuclei
abnormal photoreceptor outer segment morphology ( J:99982 )
• occasionally also affected by presence of photoreceptor nuclei

pigmentation
abnormal retina pigment epithelium morphology ( J:81149 )
• small patchy areas of RPE depigmentation and clumping

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
X-linked juvenile retinoschisis 1 DOID:0060763 OMIM:312700
 J:99982




Genotype
MGI:3784608
cx2
Allelic
Composition		 Morq1AKR/J/Morq1AKR/J
Rs1tmgc1/Y
Genetic
Background		 B6.Cg-Rs1tmgc1 Morq1AKR/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Morq1AKR/J mutation (0 available); any Morq1 mutation (0 available)
Rs1tmgc1 mutation (0 available); any Rs1 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal retina neuronal layer morphology ( J:133513 )
• resistance to retinal schisis




Genotype
MGI:3784609
cx3
Allelic
Composition		 Morq1AKR/J/Morq1AKR/J
Rs1tmgc1/Rs1tmgc1
Genetic
Background		 B6.Cg-Rs1tmgc1 Morq1AKR/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Morq1AKR/J mutation (0 available); any Morq1 mutation (0 available)
Rs1tmgc1 mutation (0 available); any Rs1 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal retina neuronal layer morphology ( J:133513 )
• resistance to retinal schisis




Genotype
MGI:3784605
cx4
Allelic
Composition		 Morq1AKR/J/Morq1AKR/J
Rs1tmgc1/Y
Genetic
Background		 involves: AKR/J * C3H/Rl * C57BL/6JRn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Morq1AKR/J mutation (0 available); any Morq1 mutation (0 available)
Rs1tmgc1 mutation (0 available); any Rs1 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal retina neuronal layer morphology ( J:133513 )
• resistance to retinal schisis




Genotype
MGI:3784606
cx5
Allelic
Composition		 Morq1AKR/J/Morq1C57BL/6JRn
Rs1tmgc1/Y
Genetic
Background		 involves: AKR/J * C3H/Rl * C57BL/6JRn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Morq1AKR/J mutation (0 available); any Morq1 mutation (0 available)
Morq1C57BL/6JRn mutation (0 available); any Morq1 mutation (0 available)
Rs1tmgc1 mutation (0 available); any Rs1 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal retina neuronal layer morphology ( J:133513 )
• susceptibility to retinal schisis




Genotype
MGI:3784607
cx6
Allelic
Composition		 Morq1AKR/J/Morq1C3H/Rl
Rs1tmgc1/Y
Genetic
Background		 involves: AKR/J * C3H/Rl * C57BL/6JRn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Morq1AKR/J mutation (0 available); any Morq1 mutation (0 available)
Morq1C3H/Rl mutation (0 available); any Morq1 mutation (0 available)
Rs1tmgc1 mutation (0 available); any Rs1 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal retina neuronal layer morphology ( J:133513 )
• susceptibility to retinal schisis




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory