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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		F2rl1tm1Wrf
targeted mutation 1, William R Ferrell
MGI:2448473
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		F2rl1tm1Wrf/F2rl1tm1Wrf involves: 129P2/OlaHsd MGI:3784946
hm2
 		F2rl1tm1Wrf/F2rl1tm1Wrf involves: 129P2/OlaHsd * C57BL/6 MGI:3784945


Genotype
MGI:3784946
hm1
Allelic
Composition		 F2rl1tm1Wrf/F2rl1tm1Wrf
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F2rl1tm1Wrf mutation (0 available); any F2rl1 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating interleukin-18 level ( J:102762 )
• induction of serum IL-18 following treatment with Propionibacterium acnes and LPS is impaired compared to in similarly treated wild-type mice
abnormal physiological response to xenobiotic ( J:81119 , J:120751 )
• mice fail to reverse ischemia-induced gastrointestinal transit delay induced by SLIGRL-NH2 unlike in wild-type mice (J:81119)
• mice fail to exhibit an increase in abdominal contractions compared to basal distension following exposure to supernatant from patients with irritable bowl syndrome unlike wild-type mice (J:120751)

immune system
decreased circulating interleukin-18 level ( J:102762 )
• induction of serum IL-18 following treatment with Propionibacterium acnes and LPS is impaired compared to in similarly treated wild-type mice
liver inflammation ( J:102762 )
• following treatment with Propionibacterium acnes and LPS, cell infiltration is observed compared to in wild-type mice that develop liver necrosis and granulomas

liver/biliary system
liver inflammation ( J:102762 )
• following treatment with Propionibacterium acnes and LPS, cell infiltration is observed compared to in wild-type mice that develop liver necrosis and granulomas




Genotype
MGI:3784945
hm2
Allelic
Composition		 F2rl1tm1Wrf/F2rl1tm1Wrf
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F2rl1tm1Wrf mutation (0 available); any F2rl1 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased physiological sensitivity to xenobiotic ( J:81119 )
• mice fail to exhibit a vasodilation, altered blood pressure or increased synovial joint swelling in response to ASKH95 unlike wild-type mice
• acute inflammatory responses to carageenan/kaolin is reduced compared to in heterozygous (26% decrease) and wild-type mice (40% decrease)
increased cerebral infarct size ( J:112482 )
• following middle cerebral artery occlusion, infarct size and number of TUNEL-positive cells was increased compared to in wild-type mice

nervous system
increased cerebral infarct size ( J:112482 )
• following middle cerebral artery occlusion, infarct size and number of TUNEL-positive cells was increased compared to in wild-type mice

immune system
decreased susceptibility to induced arthritis ( J:81119 )
• chronic joint inflammation is inhibited in mutants

skeleton
decreased susceptibility to induced arthritis ( J:81119 )
• chronic joint inflammation is inhibited in mutants




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory