Phenotypes associated with this allele

• Allele Symbol: Ptprcap^tm1Tkda
• Allele Name: targeted mutation 1, Akiko Takeda
• Allele ID: MGI:2448362
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptprcap^tm1Tkda/Ptprcap^tm1Tkda	involves: 129X1/SvJ	MGI:3818485

Genotype
MGI:3818485

hm1

• Allelic Composition: Ptprcap^tm1Tkda/Ptprcap^tm1Tkda
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:48387 )

N • normal leukocyte differentiation

decreased B cell proliferation ( J:48387 )

• reduced proliferative response of B cells to anti-IgM antibodies

decreased T cell proliferation ( J:48387 )

• significantly reduced proliferative response of T cells to TCR mediated stimuli

abnormal cytotoxic T cell physiology ( J:48387 )

• 50% reduction of cytotoxic leukocyte activity

hematopoietic system

decreased B cell proliferation ( J:48387 )

• reduced proliferative response of B cells to anti-IgM antibodies

decreased T cell proliferation ( J:48387 )

• significantly reduced proliferative response of T cells to TCR mediated stimuli

abnormal cytotoxic T cell physiology ( J:48387 )

• 50% reduction of cytotoxic leukocyte activity

cellular

decreased B cell proliferation ( J:48387 )

• reduced proliferative response of B cells to anti-IgM antibodies

decreased T cell proliferation ( J:48387 )

• significantly reduced proliferative response of T cells to TCR mediated stimuli