All Phenotypes Sox2<lcc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sox2^lcc
light coat and circling
MGI:2447995

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sox2^lcc/Sox2^lcc	involves: 101/H * C3H/HeH	MGI:3582557
ht2	Sox2^lcc/Sox2⁺	involves: 101/H * C3H/HeH	MGI:3582558
ht3	Sox2^lcc/Sox2^tm1Rlb	involves: 101/H * 129S/SvEv * C3H/HeH	MGI:3582625
ht4	Sox2^lcc/Sox2^ysb	involves: 101/H * C3H/HeH * C57BL/6 * CBA	MGI:3582556

Allelic Composition	Sox2^lcc/Sox2^lcc
Genetic Background	involves: 101/H * C3H/HeH

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox2^lcc mutation (2 available); any Sox2 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

head bobbing ( J:77358 )

• described as vigorous

circling ( J:77358 )

abnormal sensory capabilities/reflexes/nociception ( J:77358 )

• no behavioral responses to sound

hearing/vestibular/ear

abnormal inner ear morphology ( J:98458 )

absent cochlear hair cells ( J:98458 )

• no evidence of formation of inner ear hair cells at P0

decreased cochlea coiling ( J:98458 )

• undercoiled cochlea

abnormal semicircular canal morphology ( J:98458 )

• rudimentary development

small utricle ( J:98458 )

small vestibular saccule ( J:98458 )

abnormal sulcus ampullaris morphology ( J:98458 )

• absent ampullae and sensory cristae

absent cochlear nerve compound action potential ( J:77358 )

• no cochlear nerve response at any frequency

pigmentation

yellow coat color ( J:77358 )

nervous system

absent cochlear hair cells ( J:98458 )

• no evidence of formation of inner ear hair cells at P0

absent cochlear nerve compound action potential ( J:77358 )

• no cochlear nerve response at any frequency

integument

abnormal awl hair morphology ( J:77358 )

• reduced number of total awl hairs, and reduced frequency of black awls

yellow coat color ( J:77358 )

abnormal guard hair morphology ( J:77358 )

• monotrich hairs showed long subapical pheomelanin bands

abnormal zigzag hair morphology ( J:77358 )

Allelic Composition	Sox2^lcc/Sox2⁺
Genetic Background	involves: 101/H * C3H/HeH

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox2^lcc mutation (2 available); any Sox2 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

diluted coat color ( J:77358 )

behavior/neurological

head bobbing ( J:77358 )

• described as mild

integument

abnormal awl hair morphology ( J:77358 )

• reduced number of total awl hairs, and reduced frequency of black awls

diluted coat color ( J:77358 )

abnormal zigzag hair morphology ( J:77358 )

• increased number of zigzag hairs

Allelic Composition	Sox2^lcc/Sox2^tm1Rlb
Genetic Background	involves: 101/H * 129S/SvEv * C3H/HeH

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox2^lcc mutation (2 available); any Sox2 mutation (56 available)
Sox2^tm1Rlb mutation (0 available); any Sox2 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality ( J:98458 )

hearing/vestibular/ear

abnormal semicircular canal morphology ( J:98458 )

• truncated semicircular canals

small utricle ( J:98458 )

small vestibular saccule ( J:98458 )

abnormal sulcus ampullaris morphology ( J:98458 )

• absent ampullae

Allelic Composition	Sox2^lcc/Sox2^ysb
Genetic Background	involves: 101/H * C3H/HeH * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox2^lcc mutation (2 available); any Sox2 mutation (56 available)
Sox2^ysb mutation (1 available); any Sox2 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

head bobbing ( J:77358 )

• described as vigorous

circling ( J:77358 )

abnormal sensory capabilities/reflexes/nociception ( J:77358 )

• no behavioral responses to sound

hearing/vestibular/ear

absent cochlear nerve compound action potential ( J:77358 )

• no cochlear nerve response at any frequency tested

pigmentation

yellow coat color ( J:77358 )

nervous system

absent cochlear nerve compound action potential ( J:77358 )

• no cochlear nerve response at any frequency tested

integument

yellow coat color ( J:77358 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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