Phenotypes associated with this allele
Allelic Composition |
Lin7atm1Dsb/Lin7atm1Dsb
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Genetic Background |
either: (involves: 129X1/SvJ * Black Swiss) or (involves: 129X1/SvJ * C57BL/6J) |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lin7atm1Dsb mutation
(0 available);
any
Lin7a mutation
(22 available)
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lin7atm1Dsb mutation
(0 available);
any
Lin7a mutation
(22 available)
Lin7btm1Dsb mutation
(0 available);
any
Lin7b mutation
(13 available)
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normal phenotype
nervous system
N |
• although carefully examined, no abnormalities were identified in synaptic transmission
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lin7atm1Dsb mutation
(0 available);
any
Lin7a mutation
(22 available)
Lin7btm1Dsb mutation
(0 available);
any
Lin7b mutation
(13 available)
Lin7ctm1Dsb mutation
(0 available);
any
Lin7c mutation
(17 available)
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mortality/aging
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• mice die within one hour of birth
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nervous system
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• in culture, neurons from triple knock out mice show reduced EPSCs relative to wild-type
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respiratory system
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• mice exhibit irregular, labored breathing
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lin7atm1Dsb mutation
(0 available);
any
Lin7a mutation
(22 available)
Lin7btm1Dsb mutation
(0 available);
any
Lin7b mutation
(13 available)
Lin7ctm1Dsb mutation
(0 available);
any
Lin7c mutation
(17 available)
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mortality/aging
|
• mice die during second week postnatal
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