Phenotypes associated with this allele

• Allele Symbol: Tg(APOC1)1Bres
• Allele Name: transgene insertion 1, Jan L Breslow
• Allele ID: MGI:2447788
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Apoe^tm1Unc/Apoe^tm1Unc Tg(APOC1)1Bres/0	involves: 129P2/OlaHsd * C57BL/6J * CBA/J	MGI:2653531
tg2	Tg(APOC1)1Bres/Tg(APOC1)1Bres	involves: C57BL/6J * CBA/J	MGI:3714935

Genotype
MGI:2653531

cx1

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Tg(APOC1)1Bres/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

atherosclerotic lesions ( J:80689 )

• mice have more atherosclerosis compared to Apoe-deficient mice

homeostasis/metabolism

increased circulating cholesterol level ( J:80689 )

• level is ~double compared to Apoe-deficient mice

increased circulating LDL cholesterol level ( J:80689 )

• intermediate-density lipoprotein (IDL) + LDL cholesterol level is increased relative to Apoe-null mice

increased circulating VLDL cholesterol level ( J:80689 )

increased circulating triglyceride level ( J:80689 )

• levels are increased almost 10-fold in males and ~3-fold in females

increased circulating VLDL triglyceride level ( J:80689 )

• VLDL triglyceride fraction is enriched significantly compared to Apoe-deficient mice

hyperlipidemia ( J:80689 )

• more severe than Apoe-deficient littermates in fasting and non-fasting states

impaired lipolysis ( J:80689 )

increased triglyceride lipase activity ( J:80689 )

• mice show increased hepatic lipase activity relative to Apoe-deficient mice

increased lipoprotein lipase activity ( J:80689 )

• mice show increased lipoprotein lipase activity than wild-type and Apoe-null mice

Genotype
MGI:3714935

tg2

• Allelic Composition: Tg(APOC1)1Bres/Tg(APOC1)1Bres
• Genetic Background: involves: C57BL/6J * CBA/J

homeostasis/metabolism

abnormal lipid homeostasis ( J:80950 )

• lipoprotein production is normal in transgenic mice, but clearance rates are reduced

increased circulating cholesterol level ( J:80950 )

• increased by ~50%; increased absolute cholesterol level

increased circulating LDL cholesterol level ( J:80950 )

• intermediate-density lipoprotein (IDL) + HDL cholesterol level is increased ~2.6-fold

increased circulating VLDL cholesterol level ( J:80950 )

• lipoprotein profile shows increase in chylomicron + VLDL cholesterol level of 2.8-fold; half of increase in plasma cholesterol is due to VLDL fraction, while remainder is equally IDL +LDL or HDL components

increased circulating triglyceride level ( J:80950 )

• elevated ~75% in both fasted and fed states compared to controls on normal diet

• 1.4-fold increase in intermediate- + low-density lipoprotein (IDL + LDL) triglycerides is detected

• on high fat diet, levels are slightly decreased in fasted vs fed transgenics and remain constant in wild-type

increased circulating VLDL triglyceride level ( J:80950 )

• lipoprotein profile shows 1.6-fold increase in VLDL triglyceride level compared to wild-type mice

hyperlipidemia ( J:80950 )

• fasting APO C1 levels are 17 mg/dl and increase to 40 mg/dl in the fed state with normal chow (normal human level is 9 mg/dl)

• on Western diet (high fat), fasted levels are 54 mg/dl and increase to 68 mg/dl in fed state

impaired lipolysis ( J:80950 )

• hyperlipidemia results from reduced lipoprotein clearance rates