Analysis Tools
neoplasm
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• multiparous transgenic mice frequently develop mammary tumors (3-25%, with average latency period of about 10 months)
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endocrine/exocrine glands
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• mutants exhibit a higher proliferation rate of mammary epithelial cells at day 14 and 18 of pregnancy
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• delay in involution is accompanied by severe mastitis in 10-15% of transgenic mice
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• mutants exhibit delayed involution, such that at 3 days after pup removal, compaction of alveoli and loss of epithelial cells is not observed as in wild-type
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• alveoli remain small at day 3 postpartum and 6 days of lactation
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• alveolar structures occupy more of the fat pad by 14 days of pregnancy and appear denser with smaller lumens
• mutants exhibit a higher proliferation rate of mammary epithelial cells at day 14 and 18 of pregnancy
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• multiparous transgenic mice frequently develop mammary tumors (3-25%, with average latency period of about 10 months)
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• mice are able to lactate, however milk contains higher levels of milk proteins (alpha-casein, beta-casein, and gamma-casein) are found in the milk, resulting in a more rapid weight increase of pups than observed with wild-type mothers
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immune system
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• delay in involution is accompanied by severe mastitis in 10-15% of transgenic mice
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reproductive system
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• alveolar structures occupy more of the fat pad by 14 days of pregnancy and appear denser with smaller lumens
• mutants exhibit a higher proliferation rate of mammary epithelial cells at day 14 and 18 of pregnancy
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integument
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• mutants exhibit a higher proliferation rate of mammary epithelial cells at day 14 and 18 of pregnancy
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|
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• delay in involution is accompanied by severe mastitis in 10-15% of transgenic mice
|
|
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• mutants exhibit delayed involution, such that at 3 days after pup removal, compaction of alveoli and loss of epithelial cells is not observed as in wild-type
|
|
|
• alveoli remain small at day 3 postpartum and 6 days of lactation
|
|
|
• alveolar structures occupy more of the fat pad by 14 days of pregnancy and appear denser with smaller lumens
• mutants exhibit a higher proliferation rate of mammary epithelial cells at day 14 and 18 of pregnancy
|
|
• multiparous transgenic mice frequently develop mammary tumors (3-25%, with average latency period of about 10 months)
|
|
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• mice are able to lactate, however milk contains higher levels of milk proteins (alpha-casein, beta-casein, and gamma-casein) are found in the milk, resulting in a more rapid weight increase of pups than observed with wild-type mothers
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cellular
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• mutants exhibit a higher proliferation rate of mammary epithelial cells at day 14 and 18 of pregnancy
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