All Phenotypes Tg(Wnt1-cre/Esr1*)10Rth MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Wnt1-cre/Esr1*)10Rth
transgene insertion 10, David H Rowitch
MGI:2447684

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^em1Knwea/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Wnt1-cre/Esr1*)10Rth/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N	MGI:7526471
cn2	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1a(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Wnt1-cre/Esr1*)10Rth/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N	MGI:7526475
cn3	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1d(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Wnt1-cre/Esr1*)10Rth/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N	MGI:7526477
cn4	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1c(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Wnt1-cre/Esr1*)10Rth/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N	MGI:7526481

Allelic Composition	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^em1Knwea/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Wnt1-cre/Esr1*)10Rth/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} mutation (10 available); any Gt(ROSA)26Sor mutation (944 available)
Polr1a^em1Knwea mutation (0 available); any Polr1a mutation (93 available)
Polr1a^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Polr1a mutation (93 available)
Tg(Wnt1-cre/Esr1*)10Rth mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development ( J:335489 )

craniofacial

flat forehead ( J:335489 )

• starting in E9.5 embryos, worsening with age

facial cleft ( J:335489 )

growth/size/body

flat forehead ( J:335489 )

• starting in E9.5 embryos, worsening with age

facial cleft ( J:335489 )

cardiovascular system

cardiovascular system phenotype ( J:335489 )

N	• normal outflow tract septation in E12 embryos

Allelic Composition	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1a(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Wnt1-cre/Esr1*)10Rth/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} mutation (10 available); any Gt(ROSA)26Sor mutation (944 available)
Polr1a^{tm1a(EUCOMM)Hmgu} mutation (1 available); any Polr1a mutation (93 available)
Polr1a^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Polr1a mutation (93 available)
Tg(Wnt1-cre/Esr1*)10Rth mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

pharyngeal arch artery hypoplasia ( J:335489 )

• in E11.5 embryos

persistent truncus arteriosus ( J:335489 )

• in E12 embryos

decreased heart left ventricle wall thickness ( J:335489 )

• in E12.5 embryos

increased vascular permeability ( J:335489 )

• diffuse vascular leakage in E11.5 embryos

craniofacial

pharyngeal arch artery hypoplasia ( J:335489 )

• in E11.5 embryos

flat forehead ( J:335489 )

• starting in E9.5 embryos, worsening with age

embryo

pharyngeal arch artery hypoplasia ( J:335489 )

• in E11.5 embryos

growth/size/body

flat forehead ( J:335489 )

• starting in E9.5 embryos, worsening with age

mortality/aging

lethality throughout fetal growth and development ( J:335489 )

embryonic lethality during organogenesis, complete penetrance ( J:335489 )

Allelic Composition	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1d(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Wnt1-cre/Esr1*)10Rth/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} mutation (10 available); any Gt(ROSA)26Sor mutation (944 available)
Polr1a^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Polr1a mutation (93 available)
Polr1a^{tm1d(EUCOMM)Hmgu} mutation (0 available); any Polr1a mutation (93 available)
Tg(Wnt1-cre/Esr1*)10Rth mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

pharyngeal arch artery hypoplasia ( J:335489 )

• in E11.5 embryos

persistent truncus arteriosus ( J:335489 )

• in E12 embryos

decreased heart left ventricle wall thickness ( J:335489 )

• in E12.5 embryos

increased vascular permeability ( J:335489 )

• diffuse vascular leakage in E11.5 embryos

craniofacial

pharyngeal arch artery hypoplasia ( J:335489 )

• in E11.5 embryos

flat forehead ( J:335489 )

• starting in E9.5 embryos, worsening with age

embryo

pharyngeal arch artery hypoplasia ( J:335489 )

• in E11.5 embryos

growth/size/body

flat forehead ( J:335489 )

• starting in E9.5 embryos, worsening with age

mortality/aging

lethality throughout fetal growth and development ( J:335489 )

embryonic lethality during organogenesis, complete penetrance ( J:335489 )

Allelic Composition	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1c(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Wnt1-cre/Esr1*)10Rth/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} mutation (10 available); any Gt(ROSA)26Sor mutation (944 available)
Polr1a^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Polr1a mutation (93 available)
Tg(Wnt1-cre/Esr1*)10Rth mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

pharyngeal arch artery hypoplasia ( J:335489 )

• in E11.5 embryos

persistent truncus arteriosus ( J:335489 )

• in E12 embryos

decreased heart left ventricle wall thickness ( J:335489 )

• in E12.5 embryos

increased vascular permeability ( J:335489 )

• diffuse vascular leakage in E11.5 embryos

craniofacial

pharyngeal arch artery hypoplasia ( J:335489 )

• in E11.5 embryos

flat forehead ( J:335489 )

• starting in E9.5 embryos, worsening with age

embryo

pharyngeal arch artery hypoplasia ( J:335489 )

• in E11.5 embryos

growth/size/body

flat forehead ( J:335489 )

• starting in E9.5 embryos, worsening with age

mortality/aging

lethality throughout fetal growth and development ( J:335489 )

embryonic lethality during organogenesis, complete penetrance ( J:335489 )

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