Phenotypes associated with this allele

• Allele Symbol: Tg(KRT14-cre/PGR)1Der
• Allele Name: transgene insertion 1, Dennis R Roop
• Allele ID: MGI:2447651
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Krt10^tm1Der/Krt10^tm1Der Tg(KRT14-cre/PGR)1Der/0	involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR	MGI:2652793
cn2	Krt10^tm1Der/Krt10^+ Tg(KRT14-cre/PGR)1Der/0	involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR	MGI:2652794
cn3	Krt14^tm1Der/Krt14^+ Tg(KRT14-cre/PGR)1Der/?	involves: 129X1/SvJ * FVB * ICR	MGI:3812200

Genotype
MGI:2652793

cn1

• Allelic Composition: Krt10^tm1Der/Krt10^tm1Der; Tg(KRT14-cre/PGR)1Der/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:82300 )

• animals die shortly after birth

integument

abnormal epidermis stratum spinosum morphology ( J:82300 )

• complete disintegration of the stratum spinosum

blistering ( J:82300 )

• severe blistering and erosion of the skin

skin lesions ( J:82300 )

Genotype
MGI:2652794

cn2

• Allelic Composition: Krt10^tm1Der/Krt10⁺; Tg(KRT14-cre/PGR)1Der/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB * ICR

integument

hyperkeratosis ( J:82300 )

• paws exhbit epidermal hyperkeratosis after onset of hair growth; hyperkeratosis persisted 6 months after initial RU486 treatment

blistering ( J:82300 )

• blisters develop after 3-5 topical treatments with RU486

scaly skin ( J:82300 )

• animals develop mild scaling

Genotype
MGI:3812200

cn3

• Allelic Composition: Krt14^tm1Der/Krt14⁺; Tg(KRT14-cre/PGR)1Der/?
• Genetic Background: involves: 129X1/SvJ * FVB * ICR

integument

blistering ( J:67320 )

• after application of a topical antiprogestin, RU486, to the forelimbs and chest of newborn pups so that the cre transgene translocates from the cytoplasm to the nucleus of epidermal cells and becomes active, mice developed blisters filled with fluid on the front legs and paws

• blistering occurs within the basal layer of the epidermis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
epidermolysis bullosa simplex Dowling-Meara type		DOID:0060735	OMIM:131760	J:67320