All Phenotypes Pold1<tm1Bdp> MGI Mouse

premature death ( J:80306 )

• mortalitiy increased after 3 months of age

• median age at death around 10 months

• all were either dead or moribund by 18 months of age

increased tumor incidence ( J:80306 , J:100685 )

• 94% with one or more forms of cancer at death (J:80306)

• mutation rates were about 10 fold over background (J:80306)

• last to develop were tumors of internal organs including adenomas, adenocarcinomas, abdominal lymphomas, sarcomas, and teratomas starting around 9 months of age (J:80306)

• most tumors were of epithelial origin (J:80306)

• 21/49 homozygotes have developed tumors 12 months into the study compared to 0 wild-type or heterozygotes (J:100685)

• one mutant developed three tumors (J:100685)

increased skin tumor incidence ( J:80306 )

• started appearing at 7 months on areas of exposed skin such as the tail and ears

increased lymphoma incidence ( J:80306 , J:100685 )

• developed between 3 and 14 months of age (J:80306)

• 2/23 tumors are diffuse lymphomas (J:100685)

increased T cell derived lymphoma incidence ( J:100685 )

• 16 of 23 tumors are thymic lymphomas

increased lung adenocarcinoma incidence ( J:100685 )

• 1/23 is a lung adenocarcinoma

increased squamous cell carcinoma incidence ( J:100685 )

• 6/23 tumors are tail-skin squamous cell carcinomas

increased sarcoma incidence ( J:100685 )

• 2/23 tumors are sarcomas