Phenotypes associated with this allele

• Allele Symbol: Rnf2^tm1Hko
• Allele Name: targeted mutation 1, Haruhiko Koseki
• Allele ID: MGI:2447529
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rnf2^tm1Hko/Rnf2^tm1Hko	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3039291
cx2	Pcgf2^tm1Hko/Pcgf2^tm1Hko Rnf2^tm1Hko/Rnf2^tm1Hko	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3039284

Genotype
MGI:3039291

hm1

• Allelic Composition: Rnf2^tm1Hko/Rnf2^tm1Hko
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal sternum ossification ( J:79851 )

• additional ossification at the cranial end of the sternum

thoracic vertebral transformation ( J:79851 )

• spinous process of thoracic vertebra 2 found on thoracic vertebra 1 in 40% of mice (T1 becomes T2)

cervical vertebral transformation ( J:79851 )

• ectopic ribs are associated with cervical vertebra 7 in about 60% of mice (C7 becomes T1)

Genotype
MGI:3039284

cx2

• Allelic Composition: Pcgf2^tm1Hko/Pcgf2^tm1Hko; Rnf2^tm1Hko/Rnf2^tm1Hko
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

skeleton

skeleton phenotype ( J:79851 )

N • phenotypes of double homozygotes were identical to those of mice homozygous for Rnf110^tm1Hko only except as indicated

asymmetric sternocostal joints ( J:79851 )

• unilateral or bilateral rib 7 attachment to the sternum in some instances

• if rib 7 does not attach to the sternum, no vertebral abnormalities occur from the lower thoracic region posteriorly

abnormal vertebrae morphology ( J:79851 )

• if bilateral attachment of rib 7 to the sternum occurs, only the thoracolumbar transition is abnormal

• if the last rib to attach to the sternum on either side is rib 6, the occipital, cervical and cervical to thoracic abnormalities persist but vertebrae are normal from the lower thoracic region posteriorly