Phenotypes associated with this allele

• Allele Symbol: Slc9a2^tm1Ges
• Allele Name: targeted mutation 1, Gary E Shull
• Allele ID: MGI:2447441
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc9a2^tm1Ges/Slc9a2^tm1Ges	involves: 129X1/SvJ * Black Swiss	MGI:2653370

Genotype
MGI:2653370

hm1

• Allelic Composition: Slc9a2^tm1Ges/Slc9a2^tm1Ges
• Genetic Background: involves: 129X1/SvJ * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Structural abnormalities in the oxyntic mucosa of the gastric corpus in Slc9a2^tm1Ges/Slc9a2^tm1Ges mice

digestive/alimentary system

abnormal gastric parietal cell morphology ( J:46545 )

• reduced number of gastric parietal cells in the oxyntic mucosa of the gastric corpus

• parietal cells develop normally but degenerate

abnormal stomach glandular epithelium morphology ( J:46545 , J:65754 )

• reduced number of gastric parietal and zymogenic cells in the oxyntic mucosa of the gastric corpus (J:46545)

hypochlorhydria ( J:46545 )

• reduced acid secretion in adult, but not juvenile, mice

stomach inflammation ( J:65754 )

• inflammation of the glandular mucosa

• transmural infiltrate first consisting of neutrophils before becoming primarily lymphocytes and plasma cells

• developing around 10 days of age and reaching maximal intensity between 17 and 19 days after birth

endocrine/exocrine glands

abnormal gastric parietal cell morphology ( J:46545 )

• reduced number of gastric parietal cells in the oxyntic mucosa of the gastric corpus

• parietal cells develop normally but degenerate

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:46545 )

N • blood pH, hydrocarbonate (HCO₃-) and sodium concentrations, and plasma aldosterone levels did not differ from those of wild-type

immune system

stomach inflammation ( J:65754 )

• inflammation of the glandular mucosa

• transmural infiltrate first consisting of neutrophils before becoming primarily lymphocytes and plasma cells

• developing around 10 days of age and reaching maximal intensity between 17 and 19 days after birth

reproductive system

abnormal fertility/fecundity ( J:46545 )

• mating pairs yielded occasional litters but, in general, did not breed well