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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Igh-6)1Msn
transgene insertion 1, Michael S Neuberger
MGI:2447191
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Ighmtm1Msn/Ighmtm1Msn
Tg(Igh-6)1Msn/?
B6.129S-Ighmtm1Msn MGI:3815445


Genotype
MGI:3815445
cx1
Allelic
Composition
Ighmtm1Msn/Ighmtm1Msn
Tg(Igh-6)1Msn/?
Genetic
Background
B6.129S-Ighmtm1Msn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighmtm1Msn mutation (0 available); any Ighm mutation (55 available)
Tg(Igh-6)1Msn mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• there is a 25% reduction in the number of follicular B cells
• there is a 2.5-fold increase in the number of marginal zone CD21highCD23low B cells
• a larger IgMbrightIgDdull MZ area on the periphery of the follicle compared with wild-type controls
• there is a doubling in the number of CD5+B cells found in the spleen
• increased B-1a B cells are also found in the peritoneum
• the ratio of marginal zone B cell numbers to follicular B cell numbers (MZ:FO) is more than double that of wild-type mice at 4 months of age
• at 12 months of age the MZ:FO ratio is not as elevated but is still significantly higher than age-matched controls
• serum levels of IgM are undetectable in these mice

hematopoietic system
• there is a 25% reduction in the number of follicular B cells
• there is a 2.5-fold increase in the number of marginal zone CD21highCD23low B cells
• a larger IgMbrightIgDdull MZ area on the periphery of the follicle compared with wild-type controls
• there is a doubling in the number of CD5+B cells found in the spleen
• increased B-1a B cells are also found in the peritoneum
• the ratio of marginal zone B cell numbers to follicular B cell numbers (MZ:FO) is more than double that of wild-type mice at 4 months of age
• at 12 months of age the MZ:FO ratio is not as elevated but is still significantly higher than age-matched controls
• serum levels of IgM are undetectable in these mice





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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory