Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighmtm1Msn mutation
(0 available);
any
Ighm mutation
(55 available)
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immune system
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• there is a 25% reduction in the number of follicular B cells
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• there is a 2.5-fold increase in the number of marginal zone CD21highCD23low B cells
• a larger IgMbrightIgDdull MZ area on the periphery of the follicle exists compared with wild-type controls
• a reduction in MZ B cell number is observed after the administration of polyclonal IgM
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• there is a doubling in the number of CD5+B cells found in the spleen
• increased B-1a B cells are also found in the peritoneum
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• the ratio of marginal zone B cell numbers to follicular B cell numbers (MZ:FO) is more than double that of wild-type mice at 4 months of age
• at 12 months of age the MZ:FO ratio is not as elevated but is still significantly higher than age-matched controls
• this ratio can be normalized by administration of polyclonal, but not monoclonal, IgM
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• serum levels of IgM are undetectable in these mice
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hematopoietic system
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• there is a 25% reduction in the number of follicular B cells
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• there is a 2.5-fold increase in the number of marginal zone CD21highCD23low B cells
• a larger IgMbrightIgDdull MZ area on the periphery of the follicle exists compared with wild-type controls
• a reduction in MZ B cell number is observed after the administration of polyclonal IgM
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• there is a doubling in the number of CD5+B cells found in the spleen
• increased B-1a B cells are also found in the peritoneum
|
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• the ratio of marginal zone B cell numbers to follicular B cell numbers (MZ:FO) is more than double that of wild-type mice at 4 months of age
• at 12 months of age the MZ:FO ratio is not as elevated but is still significantly higher than age-matched controls
• this ratio can be normalized by administration of polyclonal, but not monoclonal, IgM
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• serum levels of IgM are undetectable in these mice
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|
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighmtm1Msn mutation
(0 available);
any
Ighm mutation
(55 available)
|
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immune system
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• B cells in the bone marrow have reduced surface expression of IgM
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• splenic B cells have enhanced surface expression of IgM and decreased expression of IgD
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• B-1a B cell population is expanded in the peritoneum
• 65% of the B220+peritoneal cells are CD51 compared with 38% of B cells in controls
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• after injection of a T cell-dependent antigen, mice have a 5-fold reduction in serum levels of antigen-specific IgG1 compared to controls
• the affinity of the IgG1 antibodies to antigen is lower than wild-type
• this defect could be rescued by the co-administration of IgM collected from the sera of non-immunized mice
• mice are also able to increase titers of IgG1 upon administration of a booster, to levels similar to that of wild-type mice
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• when mice are immunized with a T cell-independent antigen, serum levels of IgG3 are enhanced 3-fold compared to controls
• levels of other IgG levels are augmented also though specifics are not given
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• IgM serum levels are undetectable
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hematopoietic system
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• B cells in the bone marrow have reduced surface expression of IgM
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• splenic B cells have enhanced surface expression of IgM and decreased expression of IgD
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• B-1a B cell population is expanded in the peritoneum
• 65% of the B220+peritoneal cells are CD51 compared with 38% of B cells in controls
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• after injection of a T cell-dependent antigen, mice have a 5-fold reduction in serum levels of antigen-specific IgG1 compared to controls
• the affinity of the IgG1 antibodies to antigen is lower than wild-type
• this defect could be rescued by the co-administration of IgM collected from the sera of non-immunized mice
• mice are also able to increase titers of IgG1 upon administration of a booster, to levels similar to that of wild-type mice
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• when mice are immunized with a T cell-independent antigen, serum levels of IgG3 are enhanced 3-fold compared to controls
• levels of other IgG levels are augmented also though specifics are not given
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• IgM serum levels are undetectable
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighmtm1Msn mutation
(0 available);
any
Ighm mutation
(55 available)
|
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immune system
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• about one-third to one-half of mice between 12-18 months of age have auto-antibodies to cardiolipin, myeloperoxidase, and/or dsDNA
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• about one-third of mice between 12-18 months of age have elevated levels of anti-dsDNA IgG antibodies
• these levels are three standard error of means over levels found in age-matched controls
• anti-dsDNA antibodies are also found in 3-month old mice that have been repeatedly injected with LPS while none are found in controls
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• 1 mouse of 13 has overt nephritis
• 6 of 13 mice have high levels of IgG and/or C3 deposition in the kidney
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renal/urinary system
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• 1 mouse of 13 has overt nephritis
• 6 of 13 mice have high levels of IgG and/or C3 deposition in the kidney
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Allelic
Composition |
Ighmtm1Msn/Ighm+
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Genetic
Background |
involves: 129S/SvEv |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighmtm1Msn mutation
(0 available);
any
Ighm mutation
(55 available)
|
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|
immune system
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• IgM serum levels are reduced by 50%
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hematopoietic system
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• IgM serum levels are reduced by 50%
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighmtm1Msn mutation
(0 available);
any
Ighm mutation
(55 available)
Tg(Igh-6)1Msn mutation
(0 available)
|
|
|
immune system
|
|
• there is a 25% reduction in the number of follicular B cells
|
|
|
• there is a 2.5-fold increase in the number of marginal zone CD21highCD23low B cells
• a larger IgMbrightIgDdull MZ area on the periphery of the follicle compared with wild-type controls
|
|
|
• there is a doubling in the number of CD5+B cells found in the spleen
• increased B-1a B cells are also found in the peritoneum
|
|
|
• the ratio of marginal zone B cell numbers to follicular B cell numbers (MZ:FO) is more than double that of wild-type mice at 4 months of age
• at 12 months of age the MZ:FO ratio is not as elevated but is still significantly higher than age-matched controls
|
|
|
• serum levels of IgM are undetectable in these mice
|
hematopoietic system
|
|
• there is a 25% reduction in the number of follicular B cells
|
|
|
• there is a 2.5-fold increase in the number of marginal zone CD21highCD23low B cells
• a larger IgMbrightIgDdull MZ area on the periphery of the follicle compared with wild-type controls
|
|
|
• there is a doubling in the number of CD5+B cells found in the spleen
• increased B-1a B cells are also found in the peritoneum
|
|
|
• the ratio of marginal zone B cell numbers to follicular B cell numbers (MZ:FO) is more than double that of wild-type mice at 4 months of age
• at 12 months of age the MZ:FO ratio is not as elevated but is still significantly higher than age-matched controls
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• serum levels of IgM are undetectable in these mice
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Analysis Tools