Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lcp2tm1Geha mutation
(0 available);
any
Lcp2 mutation
(41 available)
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immune system
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• natural killer (NK) cells are less efficient at killing EL-4 lymphoma target cells than wild-type NK cells and fail to kill BaF/3-Rae1gamma cells
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• following alpha-GalCer-stimulated or co-culture with YAC-1 cells, IFN-gamma secretion from spleen natural killer T cells is absent
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hematopoietic system
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• natural killer (NK) cells are less efficient at killing EL-4 lymphoma target cells than wild-type NK cells and fail to kill BaF/3-Rae1gamma cells
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clnktm1Rygo mutation
(2 available);
any
Clnk mutation
(30 available)
Lcp2tm1Geha mutation
(0 available);
any
Lcp2 mutation
(41 available)
|
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|
immune system
|
• natural killer (NK) cells are less efficient at killing EL-4 lymphoma target cells than wild-type NK cells and fail to kill BaF/3-Rae1gamma cells
|
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• alpha-GalCer-stimulated IFN-gamma secretion form spleen natural killer T cells is absent despite the presence of the cells
• however, natural killer cells co-cultured with YAC-1 cells produce normal levels of IFN-gamma
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hematopoietic system
|
• natural killer (NK) cells are less efficient at killing EL-4 lymphoma target cells than wild-type NK cells and fail to kill BaF/3-Rae1gamma cells
|