Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(Prnp)1D4Lnq transgene insertion 1D4, Susan Lindquist MGI:2447139 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• cerebellar atrophy
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• develop pathology with much faster onset of about 2 months compared to hemizygous transgenic mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• frequent scratching at 5-12 months of age
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• weight loss several weeks after one year of age
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• massive neuronal loss in the cerebellar granular layer and the molecular layer, however Purkinje neurons are not affected
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/30/2025 MGI 6.24 |
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