About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(tTA)1Pjln
transgene insertion 1, Peter J Nielsen
MGI:2447131
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Pou2af1tm1Pjln/Pou2af1tm1Pjln
Tg(tetO-Pou2af1)1Pjln/0
Tg(tTA)1Pjln/0 		involves: C57BL/6 MGI:4354504


Genotype
MGI:4354504
cx1
Allelic
Composition		 Pou2af1tm1Pjln/Pou2af1tm1Pjln
Tg(tetO-Pou2af1)1Pjln/0
Tg(tTA)1Pjln/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou2af1tm1Pjln mutation (0 available); any Pou2af1 mutation (19 available)
Tg(tetO-Pou2af1)1Pjln mutation (0 available)
Tg(tTA)1Pjln mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:67362 )
N
• unlike in Pou2af1tm1Pjln homozygotes, mice exhibit normal numbers of pro-, pre-, immature, and transitional immature B cells and normal rates of B cell apoptosis
decreased B cell number ( J:67362 )
• in the spleen
decreased immunoglobulin level ( J:67362 )
• serum levels of secondary immunoglobins are greatly reduced compared to in wild-type mice

hematopoietic system
decreased B cell number ( J:67362 )
• in the spleen
decreased immunoglobulin level ( J:67362 )
• serum levels of secondary immunoglobins are greatly reduced compared to in wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory