Phenotypes associated with this allele

• Allele Symbol: Tg(IL2-Il10)1Kro
• Allele Name: transgene insertion 1, Mitchell Kronenberg
• Allele ID: MGI:2447078
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(IL2-Il10)1Kro/0	involves: C3H * C57BL/6	MGI:2652163

Genotype
MGI:2652163

tg1

• Allelic Composition: Tg(IL2-Il10)1Kro/0
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal cytokine secretion ( J:41588 )

• increased IL10 secretion

• decreased IFN-gamma secretion

increased susceptibility to bacterial infection ( J:80569 )

• increased susceptibility to reactivation of tuberculosis with Mycobacterium tuberculosis

• increased bacterial numbers in lungs after reinfection

• 200 days after tuberculosis reactivation animals displayed foamy macrophage-dominated lung lesions

decreased susceptibility to parasitic infection ( J:41588 )

• increased resistance to Leishmania major infection